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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DLGAP3  -  discs, large (Drosophila) homolog...

Homo sapiens

Synonyms: DAP-3, DAP3, Disks large-associated protein 3, PSD-95/SAP90-binding protein 3, SAP90/PSD-95-associated protein 3, ...
 
 
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High impact information on DLGAP3

  • Sequence analysis revealed an 82% amino acid identity to the human death associated protein 3 (hDAP-3), a positive mediator of apoptosis [1].
  • Studies of cultured cells from dap3-/- embryos confirmed a role in apoptosis induced by stimuli that trigger the extrinsic (TNFalpha, TRAIL, anti-Fas antibody) but not intrinsic (mitochondrial) cell death pathway [2].
  • The dap3-/- embryos and placentas were markedly shrunken [2].
  • Levels of cytochrome c oxidase-I, a protein encoded in the mitochondrial genome, were reduced in dap3-/- embryos, consistent with a role for DAP3 in intramitochondrial protein synthesis [2].
  • Transmission electron microscopy analysis revealed abnormal, shrunken mitochondria with swollen crystae in dap3-/- embryos [2].

References

  1. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. Berger, T., Brigl, M., Herrmann, J.M., Vielhauer, V., Luckow, B., Schlöndorff, D., Kretzler, M. J. Cell. Sci. (2000) [Pubmed]
  2. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim, H.R., Chae, H.J., Thomas, M., Miyazaki, T., Monosov, A., Monosov, E., Krajewska, M., Krajewski, S., Reed, J.C. FASEB J. (2007) [Pubmed]
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