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Gene Review

Myoz2  -  myozenin 2

Mus musculus

Synonyms: 1110012I24Rik, Calsarcin-1, FATZ-related protein 2, Fatz-2, Myozenin-2, ...
 
 
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Disease relevance of Myoz2

  • The absence of calsarcin-1 also activated a hypertrophic gene program, despite the absence of hypertrophy, and enhanced the cardiac growth response to pressure overload [1].
 

High impact information on Myoz2

 

Other interactions of Myoz2

References

  1. Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Frey, N., Barrientos, T., Shelton, J.M., Frank, D., Rütten, H., Gehring, D., Kuhn, C., Lutz, M., Rothermel, B., Bassel-Duby, R., Richardson, J.A., Katus, H.A., Hill, J.A., Olson, E.N. Nat. Med. (2004) [Pubmed]
  2. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. Frey, N., Olson, E.N. J. Biol. Chem. (2002) [Pubmed]
  3. NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but not calsarcin-2, in C2C12 cells. Wang, H., Yang, S., Yang, E., Zhu, Z., Mu, Y., Feng, S., Li, K. BMC Mol. Biol. (2007) [Pubmed]
 
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