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Gene Review: 

Prl8a4  -  prolactin family 8, subfamily a, member 4

Rattus norvegicus

Synonyms: Growth hormone-related placental protein 3, PLP-H, PRL-like protein H, Placental prolactin-like protein H, Prlph, ...
 
 
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High impact information on Prl8a4

  • The predicted protein shares 55-66% amino acid identity with mouse PLP-Calpha and rat PLP-D, PLP-H, PLP-Cv, and PLP-C and also contains 6 homologously positioned cysteine residues [1].
  • We prepared a recombinant protein for PLP-H together with PLP-D using a COS7 transfection system [2].
  • PLP-H contains two putative N-glycosylation sites and eight cysteine residues, of which six are highly conserved in the placental PRL family [2].
  • Only the 27-kDa protein was detected after N-glycosidase treatment, indicating that PLP-H is a glycoprotein [2].
  • In situ hybridization analysis indicated that PLP-H mRNA is specifically expressed in spongiotrophoblast cells and in trophoblast giant cells of the placental junctional zone [2].
 

Analytical, diagnostic and therapeutic context of Prl8a4

References

  1. Identification and characterization of a new member of the placental prolactin-like protein-C (PLP-C) subfamily, PLP-Cbeta. Hwang, I.T., Lee, Y.H., Moon, B.C., Ahn, K.Y., Lee, S.W., Chun, J.Y. Endocrinology (2000) [Pubmed]
  2. Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H. Iwatsuki, K., Oda, M., Sun, W., Tanaka, S., Ogawa, T., Shiota, K. Endocrinology (1998) [Pubmed]
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