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Gene Review

RBM4  -  RNA binding motif protein 4

Homo sapiens

Synonyms: LARK, Lark homolog, RBM4A, RNA-binding motif protein 4, RNA-binding motif protein 4a, ...
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Disease relevance of RBM4

  • Our work also suggests that down-regulating tau exon 10 splicing activators, such as RBM4, may be of therapeutic potential in tauopathies involving excessive tau exon 10 inclusion [1].

High impact information on RBM4

  • TRN-SR2 interacts specifically with RBM4 in a Ran-sensitive manner [2].
  • Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB [3].
  • This study suggests a possible mechanism underlying the regulated alternative splicing of alpha-TM by the antagonistic splicing regulators RBM4 and PTB [3].
  • Using minigenes, we demonstrated that RBM4 can activate the selection of skeletal muscle-specific exons, possibly via binding to intronic pyrimidine-rich elements [3].
  • Immunohistological analyses reveal that RBM4 is expressed in the human brain regions affected in tauopathy, including the hippocampus and frontal cortex [1].

Biological context of RBM4

  • TRN-SR2 indeed mediates the nuclear import of a recombinant protein containing the RBM4 C-terminal domain [2].
  • A putative intronic splicing enhancer located in intron 10 of the tau gene is required for the splicing stimulatory activity of RBM4 [1].
  • In cells transfected with a tau minigene, RBM4 overexpression leads to an increased inclusion of exon 10, whereas RBM4 down-regulation decreases exon 10 inclusion [1].
  • RBM4 conferred dose-dependent and cell-specific regulation of alternative splicing of pre-mRNAs transcribed from several reporter genes [4].

Physical interactions of RBM4


Other interactions of RBM4


Analytical, diagnostic and therapeutic context of RBM4


  1. RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion. Kar, A., Havlioglu, N., Tarn, W.Y., Wu, J.Y. J. Biol. Chem. (2006) [Pubmed]
  2. A novel splicing regulator shares a nuclear import pathway with SR proteins. Lai, M.C., Kuo, H.W., Chang, W.C., Tarn, W.Y. EMBO J. (2003) [Pubmed]
  3. Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Lin, J.C., Tarn, W.Y. Mol. Cell. Biol. (2005) [Pubmed]
  4. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Markus, M.A., Heinrich, B., Raitskin, O., Adams, D.J., Mangs, H., Goy, C., Ladomery, M., Sperling, R., Stamm, S., Morris, B.J. Exp. Cell Res. (2006) [Pubmed]
  5. Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties. Markus, M.A., Morris, B.J. DNA Cell Biol. (2006) [Pubmed]
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