Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

GAS5 - growth arrest-specific 5 (non-protein coding)

Homo sapiens

Synonyms: NCRNA00030, SNHG2

Smith, C.M. et al., Rozental, R. et al., Hirose, T. et al., Haywood, M.E. et al., Bek, M.F. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GAS5

Transfection experiments showed that synthesis of gas5-encoded U75 and U76 snoRNAs dropped significantly for mutant constructs possessing longer or shorter spacers between the snoRNA and the 3' splice site [1].
Arrest of cell growth or inhibition of translation by cycloheximide, pactamycin, or rapamycin-which specifically inhibits the translation of 5'TOP mRNAs-results in accumulation of the gas5 spliced RNA [2].
Encoded within the 11 introns of the mouse gas5 gene are nine (10 in human) box C/D snoRNAs predicted to function in the 2'-O-methylation of rRNA [2].
Classification of gas5 as a 5'TOP gene provides an explanation for why it is a growth arrest specific transcript: while the spliced gas5 RNA is normally associated with ribosomes and rapidly degraded, during arrested cell growth it accumulates in mRNP particles, as has been reported for other 5'TOP messages [2].
Superoxide anions and H(2)O(2) increased mRNA and protein expression of GAS5 (growth arrest-specific protein 5) and CHOP (C/EBP homology protein) [3].

Biological context of GAS5

In basal conditions, cellular proliferation was enhanced in the ID-1 transfectants and inhibited in the GAS5 transfectants when compared with control MK31 cells [4].
Application of cytokines that promote neuronal lineage commitment and cell cycle exit resulted in down-regulation of ID-1 and upregulation of GAS5 transcripts, whereas additional cytokine paradigms that promoted terminal neuronal differentiation resulted in the delayed down-regulation of GAS5 mRNA [4].
The murine gas5 gene was originally isolated based on its preferential expression in the growth arrest phase of the cell cycle [5].
Sequencing of the promoter regions of Gas5 has revealed polymorphisms in the BXSB strain, which may account for the differential expression profile [6].

References

Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells. Hirose, T., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Smith, C.M., Steitz, J.A. Mol. Cell. Biol. (1998) [Pubmed]
Expression and function of C/EBP homology protein (GADD153) in podocytes. Bek, M.F., Bayer, M., Müller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T.B., Benzing, T., Pavenstädt, H. Am. J. Pathol. (2006) [Pubmed]
Temporal expression of neuronal connexins during hippocampal ontogeny. Rozental, R., Srinivas, M., Gökhan, S., Urban, M., Dermietzel, R., Kessler, J.A., Spray, D.C., Mehler, M.F. Brain Res. Brain Res. Rev. (2000) [Pubmed]
The gas 5 gene shows four alternative splicing patterns without coding for a protein. Raho, G., Barone, V., Rossi, D., Philipson, L., Sorrentino, V. Gene (2000) [Pubmed]
Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Haywood, M.E., Rose, S.J., Horswell, S., Lees, M.J., Fu, G., Walport, M.J., Morley, B.J. Genes Immun. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.