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Gene Review

SMAP1  -  small ArfGAP 1

Homo sapiens

Synonyms: FLJ13159, SMAP-1, Stromal membrane-associated protein 1
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High impact information on SMAP1

  • Intriguingly, SMAP1 binds directly to the clathrin heavy chain via its clathrin-box and mutation studies revealed that its GAP domain and clathrin-box both contribute to the role SMAP1 plays in clathrin-dependent endocytosis [1].
  • SMAP1 gene localizes to 6q13 and is probably implicated in erythropoiesis, therefore it remains as an interesting candidate gene [2].
  • Cloning, characterization and chromosome mapping of the human SMAP1 gene [2].
  • The high sequence conservation between murine and human SMAP1, as well as its expression in bone marrow, strongly suggest conserved functions of this protein in both organisms [2].
  • The expression of smap-1 in erythropoietic organs as well as the correlation with the erythropoietic activity of the haematopoietic organs suggest that smap-1 is induced in stromal cells by the contact with erythroid cells, defining smap-1 as a key molecule that induced an erythropoietic microenvironment in haematopoietic organs [2].

Biological context of SMAP1

  • SMAP1 overexpression had no effect on clathrin-independent endocytosis, however [1].
  • This gene is composed of 11 exons and encodes a 468-amino-acid protein, which shows an 86% of homology with the murine smap-1 protein [2].
  • By transfection of the anti-sense smap-1 cDNA into the stromal cells, we showed that SMAP-1 may have a stimulatory effect on stroma-supported erythropoiesis [3].

Anatomical context of SMAP1


Other interactions of SMAP1


  1. A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. Tanabe, K., Torii, T., Natsume, W., Braesch-Andersen, S., Watanabe, T., Satake, M. Mol. Biol. Cell (2005) [Pubmed]
  2. Cloning, characterization and chromosome mapping of the human SMAP1 gene. Marcos, I., Borrego, S., Rodríguez de Córdoba, S., Galán, J.J., Antiñolo, G. Gene (2002) [Pubmed]
  3. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. Sato, Y., Hong, H.N., Yanai, N., Obinata, M. J. Biochem. (1998) [Pubmed]
  4. Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology. Tanabe, K., Kon, S., Natsume, W., Torii, T., Watanabe, T., Satake, M. Cancer Sci. (2006) [Pubmed]
  5. Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa. Barragan, I., Marcos, I., Borrego, S., Antiñolo, G. Int. J. Mol. Med. (2005) [Pubmed]
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