The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SMS  -  spermine synthase

Bos taurus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SMS

  • A number of N-alkylated-1,3-diaminopropane derivatives [H2N-(CH2)3-NH-(CH2)nH, where n = 1-9] have been tested as potential inhibitors of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase [1].
 

High impact information on SMS

 

Chemical compound and disease context of SMS

  • A series of mono- and geminal difluorinated analogues of spermidine (4-azaoctane-1,8-diamine) have been tested as potential substrates of partially purified rat hepatoma (HTC) cell or pure bovine spleen spermine synthase (EC 2.5.1.22) [5].
 

Biological context of SMS

 

Associations of SMS with chemical compounds

 

Analytical, diagnostic and therapeutic context of SMS

References

  1. Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells. Baillon, J.G., Kolb, M., Mamont, P.S. Eur. J. Biochem. (1989) [Pubmed]
  2. Polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain. Raina, A., Hyvönen, T., Eloranta, T., Voutilainen, M., Samejima, K., Yamanoha, B. Biochem. J. (1984) [Pubmed]
  3. Inhibitors of polyamine biosynthesis. 9. Effects of S-adenosyl-L-methionine analogues on mammalian aminopropyltransferases in vitro and polyamine biosynthesis in transformed lymphocytes. Pankaskie, M.C., Abdel-Monem, M.M., Raina, A., Wang, T., Foker, J.E. J. Med. Chem. (1981) [Pubmed]
  4. Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain. Pajula, R.L., Raina, A. FEBS Lett. (1979) [Pubmed]
  5. Fluorinated analogues of spermidine as substrates of spermine synthase. Baillon, J.G., Mamont, P.S., Wagner, J., Gerhart, F., Lux, P. Eur. J. Biochem. (1988) [Pubmed]
  6. Bioavailability of ruminally protected sulfamethoxazole after oral administration in ruminating calves. Nishida, Y., Takahashi, Y., Oda, K., Hayama, T. J. Vet. Med. Sci. (1997) [Pubmed]
  7. Regulation of pancreatic tyrosine kinase and phosphatase activities by cholecystokinin and somatostatin. Rivard, N., Lebel, D., Lainé, J., Morisset, J. Am. J. Physiol. (1994) [Pubmed]
  8. Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain. Pajula, R.L., Raina, A., Eloranta, T. Eur. J. Biochem. (1979) [Pubmed]
  9. Purification of spermine synthase from bovine brain by spermine-Sepharose affinity chromatography. Pajula, R.L., Raina, A., Kekoni, J. FEBS Lett. (1978) [Pubmed]
 
WikiGenes - Universities