Disease relevance of RPS25

• Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins [1].
• We have uncovered a cellular model system, which selectively induces the ribosomal protein S25 gene in hepatoma cells that are stressed by nutrient deprivation [2].

High impact information on RPS25

• The nuclear and nucleolar targeting properties of human ribosomal protein S25 (RPS25) were analysed by the expression of epitope-tagged RPS25 cDNAs in Cos-1 cells [1].
• The tagged RPS25 was localized to the cell nucleus, with a strong predominance in the nucleolus [1].
• Assignment of the human ribosomal protein S25 gene (RPS25) to chromosome 11q23.3 by sequence analysis of the marker D11S456 [3].
• Regulation of ribosomal protein S25 in HL60 cells isolated for resistance to adriamycin [4].

Analytical, diagnostic and therapeutic context of RPS25

• Immunofluorescence analyses demonstrated a 17 residue peptide of RPS25 as a potential nuclear/nucleolar targeting signal [1].
• Western-blot analysis using antibodies directed against a synthetic peptide based on the deduced aa sequence identifies the gene product as the human ribosomal protein S25 [5].

References