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Gene Review:

PKNOX2 - PBX/knotted 1 homeobox 2

Homo sapiens

Synonyms: Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2, PREP2

Fognani, C. et al., Imoto, I. et al., Mee, L. et al.

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High impact information on PKNOX2

The linkage disequilibrium (LD) and haplotype analyses of single nucleotide polymorphism (SNP) markers helped to further restrict the HLS locus to 476 kb between genes PKNOX2 and DDX25 [1].
Genomic organization of PKNOX2 also showed high similarity to PKNOX1, though PKNOX2 lies on a different chromosomal region, 11q24 [2].
Identification and characterization of human PKNOX2, a novel homeobox-containing gene [2].
Nuclear localization of PKNOX2 was confirmed by transfection of epitope-tagged cDNA [2].
Heterodimerization with PBX1 appears to be essential for nuclear localization of both PREP2 and PBX1 [3].

Biological context of PKNOX2

A comparison between the functional properties of PREP1 and PREP2 reveals that PREP2-PBX display a faster DNA-dissociation rate than PREP1-PBX heterodimers, suggesting different roles in controlling gene expression [3].

Other interactions of PKNOX2

Unlike PKNOX1, which was broadly expressed in many tissues, PKNOX2 showed a more restricted pattern of mRNA expression [2].
The analysis of some PREP2 in vitro properties suggests a functional diversification among PREP and between PREP and MEIS MEINOX proteins [3].

References

Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1. Mee, L., Honkala, H., Kopra, O., Vesa, J., Finnilä, S., Visapää, I., Sang, T.K., Jackson, G.R., Salonen, R., Kestilä, M., Peltonen, L. Hum. Mol. Genet. (2005) [Pubmed]
Identification and characterization of human PKNOX2, a novel homeobox-containing gene. Imoto, I., Sonoda, I., Yuki, Y., Inazawa, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Fognani, C., Kilstrup-Nielsen, C., Berthelsen, J., Ferretti, E., Zappavigna, V., Blasi, F. Nucleic Acids Res. (2002) [Pubmed]

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PKNOX2	Bos taurus
PKNOX2	Canis lupus familiaris
pknox2	Danio rerio
PKNOX2	Gallus gallus
PKNOX2	Macaca mulatta
Pknox2	Mus musculus
PKNOX2	Pan troglodytes
Pknox2	Rattus norvegicus
pknox2	Xenopus (Silurana) tropicalis

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