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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDX25  -  DEAD (Asp-Glu-Ala-Asp) box helicase 25

Homo sapiens

Synonyms: ATP-dependent RNA helicase DDX25, DEAD box protein 25, GRTH, Gonadotropin-regulated testicular RNA helicase
 
 
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Disease relevance of DDX25

  • METHODS: Mutation screening of exons and intron/exon boundaries of GRTH gene was carried out by denaturing high-performance liquid chromatography (DHPLC) in 347 infertile patients with idiopathic azoospermia and severe oligozoospermia as well as 201 fertile men [1].
 

High impact information on DDX25

 

Biological context of DDX25

  • These findings indicate that a differential pattern of transcriptional regulation may be involved in the control of GRTH gene expression in a cell-specific manner [3].
  • The 20-kb mouse GRTH gene contains 12 coding exons and all but one of its conserved helicase motifs are contained within single exons [3].
  • GRTH is a TATA-less gene with multiple transcriptional start sites (TSS), GC-rich sequences and a promoter located within -205/+63 bp of the gene [3].
  • To test this hypothesis, we investigated the possible association between the variations of the GRTH gene and human spermatogenesis impairment [1].
  • Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment [1].
 

Anatomical context of DDX25

  • In this study, GRTH antibodies specific to N- or C-terminal sequences showed differential subcellular expression of GRTH 56- and 61-kDa species in nucleus and cytoplasm, respectively, of rodent testis and transfected COS1 cells [2].

References

  1. Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment. A, Z., Zhang, S., Yang, Y., Ma, Y., Lin, L., Zhang, W. Hum. Reprod. (2006) [Pubmed]
  2. Gonadotropin-regulated Testicular RNA Helicase (GRTH/Ddx25) Is a Transport Protein Involved in Gene-specific mRNA Export and Protein Translation during Spermatogenesis. Sheng, Y., Tsai-Morris, C.H., Gutti, R., Maeda, Y., Dufau, M.L. J. Biol. Chem. (2006) [Pubmed]
  3. Genomic organization and transcriptional analysis of gonadotropin-regulated testicular RNA helicase--GRTH/DDX25 gene. Tsai-Morris, C.H., Lei, S., Jiang, Q., Sheng, Y., Dufau, M.L. Gene (2004) [Pubmed]
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