Disease relevance of HMBOX1

• Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region [1].
• PBX1 is a homeobox-containing gene identified as the chromosome 1 participant of the t(1;19) chromosomal translocation of childhood pre-B-cell acute lymphoblastic leukemia [2].
• HOX2.2 and -2.3 homeobox-containing cDNAs were cloned from an erythroleukemia cell (HEL) cDNA library, while the homeobox cDNA PL1 was isolated from a monocytic cell (U-937) library [3].
• These data, in conjunction with recent data implicating other homeobox-containing genes in the pathogenesis of human leukemias, suggest that overexpression of HB24 in hematopoietic progenitors or T-cells may contribute to oncogenic transformation [4].
• Alternatively spliced homeobox-containing cDNAs, corresponding to the major transcripts, have been cloned from two myeloid leukemia cell libraries [5].

Psychiatry related information on HMBOX1

• The homeobox-containing aristaless-related protein ARX has been directly linked to the development of a number of human disorders involving mental retardation and epilepsy and clearly plays a critical role in development of the vertebrate central nervous system [6].

High impact information on HMBOX1

• We have isolated a homeobox-containing gene (SHOX) from this region, which has at least two alternatively spliced forms, encoding proteins with different patterns of expression [7].
• The paired-class homeobox-containing gene, Cart1, is expressed in forebrain mesenchyme, branchial arches, limb buds and cartilages during embryogenesis [8].
• extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1 [9].
• By screening a Chlorohydra viridissima cDNA library with a 'guessmer' oligonucleotide, we have cloned several such cnidarian homeobox-containing genes (cnox genes) [10].
• These findings suggest that homeobox-containing genes that normally act as transcription factors may contribute to T-cell leukemogenesis when abnormally expressed [11].

Biological context of HMBOX1

• According to the genome database, HMBOX1 is located at the boundary of 8p12.3 and 8p21 [12].
• Co-transfection of HEK-293T cells with pM-HMBOX1 plasmid and reporter plasmid pGAL4(5)tkLUC indicates that HMBOX1 is a transcription repressor [12].
• To isolate homeobox-containing sequences from the plant Arabidopsis thaliana, a cDNA library was screened with a highly degenerate oligonucleotide corresponding to a conserved eight amino acid sequence from the helix-3 region of the homeodomain [13].
• Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2 [14].
• We investigated the role of homeobox-containing genes in human hematopoiesis because homeobox genes (i) control cell fate in the Drosophila embryo, (ii) are expressed in specific patterns in human embryos, and (iii) appear to function as transcription factors that control cell phenotype in other mammalian organs [3].

Anatomical context of HMBOX1

• Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines [3].
• Thyroid transcription factor gene 1 (TTF-1) is a homeobox-containing gene involved in thyroid organogenesis [15].
• Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain [16].
• The expression pattern of Otx2, a homeobox-containing gene, was analyzed from the beginning of eye morphogenesis until neural retina differentiation in chick embryos [17].
• Data obtained while investigating growth plate chondrocyte differentiation during endochondral bone formation both in vivo and in vitro indicate that initial chondrogenesis depends on positional signaling mediated by selected homeobox-containing genes and soluble mediators [18].

Associations of HMBOX1 with chemical compounds

• Genes reported to be expressed during the implantation window and implicated in progesterone action, i.e. secretoglobin family 2A, member 2 (mammaglobin) and homeobox-containing proteins, were up-regulated in uncultured LATE-P-phase endometrium compared to M-phase endometrium [19].
• Identification of a homeobox-containing gene with enhanced expression during soybean (Glycine max L.) somatic embryo development [20].
• Retinoic acid down-regulates the expression of EmH-3 homeobox-containing gene in the freshwater sponge Ephydatia muelleri [21].

Physical interactions of HMBOX1

• Recent observations have demonstrated the expression of several members of the homeobox-containing (HOX) gene complexes within the hematopoietic compartment [22].

Regulatory relationships of HMBOX1

• Identification of homeobox-containing genes expressed in hematopoietic blast cells [23].

Other interactions of HMBOX1

• Identification and characterization of human PKNOX2, a novel homeobox-containing gene [24].
• HOXD13, the homeobox-containing gene located at the most 5' end of the HOXD cluster, plays a critical role in limb development [25].
• Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21 [26].
• Characterization and sequence analysis of the human homeobox-containing gene GBX2 [27].
• Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe [28].

Analytical, diagnostic and therapeutic context of HMBOX1

• Sequence analysis revealed that tcl-3 is a new homeobox-containing gene [11].
• This paper reports the cloning and sequencing of a quail homeobox-containing gene, Quox-1, and its expression pattern in embryos from 3 to 6 days (E3 to E6) of development as determined by in situ hybridization [29].
• Amplification of each isoform by reverse transcriptase-polymerase chain reaction revealed that all of the three isoforms are expressed in fetal and adult hearts and that the homeobox-containing isoform CSX1a is most abundant [30].
• Using gene targeting in mice, we have undertaken a systematic mutational analysis of the homeobox-containing 5' HoxD genes [31].
• The polymerase chain reaction (PCR) has been used to prepare probes of homeobox-containing genes [32].

References