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Gene Review:

RBKS - ribokinase

Homo sapiens

Synonyms: DKFZp686G13268, RBSK, Ribokinase

Maugeri, D.A. et al., Schumacher, M.A. et al., Spychala, J. et al., Ito, S. et al., Long, M.C. et al.

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High impact information on RBKS

In contrast, two regions were identified with significant sequence identity to microbial ribokinase and fructokinases and a bacterial inosine/guanosine kinase [1].
Adenosine kinase (AK) is a key purine metabolic enzyme from the opportunistic parasitic protozoan Toxoplasma gondii and belongs to the family of carbohydrate kinases that includes ribokinase [2].
The enzyme shows greater sequence homology with ribokinase and fructokinase than it does with other AKs [3].
Moreover, free ribose is incorporated efficiently, implying the presence of a ribose uptake system and also of ribokinase [4].
Unexpectedly, the structure was similar to those of two ATP-dependent kinases, ribokinase and adenosine kinase [5].

Associations of RBKS with chemical compounds

Ribose was shown to be accumulated by a carrier mediated process in L. mexicana promastigotes and ribokinase activity was also measured in these cells [4].

References

Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Spychala, J., Datta, N.S., Takabayashi, K., Datta, M., Fox, I.H., Gribbin, T., Mitchell, B.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. Schumacher, M.A., Scott, D.M., Mathews, I.I., Ealick, S.E., Roos, D.S., Ullman, B., Brennan, R.G. J. Mol. Biol. (2000) [Pubmed]
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis. Long, M.C., Escuyer, V., Parker, W.B. J. Bacteriol. (2003) [Pubmed]
Pentose phosphate metabolism in Leishmania mexicana. Maugeri, D.A., Cazzulo, J.J., Burchmore, R.J., Barrett, M.P., Ogbunude, P.O. Mol. Biochem. Parasitol. (2003) [Pubmed]
Structural basis for the ADP-specificity of a novel glucokinase from a hyperthermophilic archaeon. Ito, S., Fushinobu, S., Yoshioka, I., Koga, S., Matsuzawa, H., Wakagi, T. Structure (Camb.) (2001) [Pubmed]

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AgaP_AGAP002608	Anopheles gambiae str. PEST
AT1G17160	Arabidopsis thaliana
RBKS	Bos taurus
F07A11.5	Caenorhabditis elegans
RBKS	Canis lupus familiaris
rbks	Danio rerio
CG13369	Drosophila melanogaster
RBKS	Gallus gallus
KLLA0C03498g	Kluyveromyces lactis NRRL Y-1140
RBKS	Macaca mulatta
MGG_06089	Magnaporthe oryzae 70-15
Rbks	Mus musculus
NCU04339	Neurospora crassa OR74A
Os01g0665400	Oryza sativa Japonica Group
RBKS	Pan troglodytes
Rbks	Rattus norvegicus
RBK1	Saccharomyces cerevisiae S288c
SPBC16G5.02c	Schizosaccharomyces pombe 972h-
rbks	Xenopus (Silurana) tropicalis

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