The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ADK  -  adenosine kinase

Homo sapiens

Synonyms: AK, Adenosine 5'-phosphotransferase, Adenosine kinase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ADK


Psychiatry related information on ADK

  • We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity [6].

High impact information on ADK


Chemical compound and disease context of ADK


Biological context of ADK


Anatomical context of ADK


Associations of ADK with chemical compounds

  • 3. DNA fragmentation evoked by 2-CADO was inhibited by NBMPR and by 5'-iodotubercidin, an adenosine kinase inhibitor, but not by xanthine amine congener, an A(1) and A(2) receptor antagonist, or by selective AdoR antagonists [19].
  • Pretreatment of the mutants with the ADK inhibitor 5-iodotubercidin led to lesions similar to those in WT mice [2].
  • RESULTS: The results clearly showed almost identical preventive and curative effects of melatonin on the growth of DMBA-induced mammary ADK [12].
  • However, seizures in kainic acid-injected mutants displayed increased intra-ictal spike frequency compared with wild-type mice, indicating that, once epilepsy is established, increased levels of ADK aggravate seizure severity [13].
  • The 3/4 NX rats were divided into three groups (C, control, n = 7; AD, captopril (an ACEI) +80% restriction diet (RD), n = 8; and ADK, ACEI + RD + AST-120, n = 8) and survival was observed for 72 weeks [14].

Regulatory relationships of ADK


Other interactions of ADK


Analytical, diagnostic and therapeutic context of ADK

  • We determined the structure of human adenosine kinase by X-ray crystallography using MAD phasing techniques and refined the structure to 1.5 A resolution [23].
  • Since ontogeny of the adenosine system is largely unknown, we investigated ADK expression and cellular localization during postnatal development of the mouse brain, using immunofluorescence staining with cell-type specific markers [18].
  • In recent years, novel treatment strategies have been developed that make use of the intracerebral transplantation of cells that are ADK deficient and, thus, release adenosine [1].
  • A combination of protein kinase A type II (RII) overlay screening, database searches and PCR was used to identify a centrosomal A-kinase anchoring protein [24].
  • The inhibition of cell stiffening was associated with an increase in intracellular cAMP as measured by enzyme-linked immunoassay (EIA) and an increase in the activity of the cAMP-dependent kinase (A-kinase) [25].


  1. Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Boison, D. Trends Pharmacol. Sci. (2006) [Pubmed]
  2. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. Pignataro, G., Simon, R.P., Boison, D. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  3. Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients. Gatteschi, B., Costantini, M., Bruzzi, P., Merlo, F., Torcoli, R., Nicolo, G. Int. J. Cancer (1991) [Pubmed]
  4. Tumour CEA as predictor of better outcome in squamous cell carcinoma of the lung. Veronesi, G., Pelosi, G., Sonzogni, A., Leon, M.E., D'Aiuto, M., Gasparri, R., De Braud, F., De Pas, T., Sandri, M., Spaggiari, L. Lung Cancer (2005) [Pubmed]
  5. Interaction between novel anticancer agents and radiation in non-small cell lung cancer cell lines. Loprevite, M., Favoni, R.E., de Cupis, A., Pirani, P., Pietra, G., Bruno, S., Grossi, F., Scolaro, T., Ardizzoni, A. Lung Cancer (2001) [Pubmed]
  6. Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity. Zheng, G.Z., Mao, Y., Lee, C.H., Pratt, J.K., Koenig, J.R., Perner, R.J., Cowart, M.D., Gfesser, G.A., McGaraughty, S., Chu, K.L., Zhu, C., Yu, H., Kohlhaas, K., Alexander, K.M., Wismer, C.T., Mikusa, J., Jarvis, M.F., Kowaluk, E.A., Stewart, A.O. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  7. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., Scott, J.D. Science (1996) [Pubmed]
  8. Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes. Hershfield, M.S., Snyder, F.F., Seegmiller, J.E. Science (1977) [Pubmed]
  9. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Linden, J. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  10. Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. Gao, W.Y., Shirasaka, T., Johns, D.G., Broder, S., Mitsuya, H. J. Clin. Invest. (1993) [Pubmed]
  11. Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity. Loprevite, M., Favoni, R.E., de Cupis, A., Pirani, P., Merlo, F., Grossi, F., Ardizzoni, A. Int. J. Oncol. (1999) [Pubmed]
  12. Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague-Dawley rat. Lenoir, V., de Jonage-Canonico, M.B., Perrin, M.H., Martin, A., Scholler, R., Kerdelhué, B. Breast Cancer Res. (2005) [Pubmed]
  13. Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. Fedele, D.E., Gouder, N., Güttinger, M., Gabernet, L., Scheurer, L., Rülicke, T., Crestani, F., Boison, D. Brain (2005) [Pubmed]
  14. Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet. Imai, E., Takenaka, M., Isaka, Y., Moriyama, T., Akagi, Y., Kakuchi, J., Fujii, T., Ito, T., Hori, M., Horio, M., Syoji, T., Tsubakihara, Y. Clin. Exp. Nephrol. (2003) [Pubmed]
  15. Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Spychala, J., Datta, N.S., Takabayashi, K., Datta, M., Fox, I.H., Gribbin, T., Mitchell, B.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  16. Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons. Singh, B., Lin, A., Wu, Z.C., Gupta, R.S. DNA Cell Biol. (2001) [Pubmed]
  17. Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel. Klobutcher, L.A., Nichols, E.A., Kucherlapati, R.S., Ruddle, F.H. Cytogenet. Cell Genet. (1976) [Pubmed]
  18. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Studer, F.E., Fedele, D.E., Marowsky, A., Schwerdel, C., Wernli, K., Vogt, K., Fritschy, J.M., Boison, D. Neuroscience (2006) [Pubmed]
  19. 2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling. Koshiba, M., Kosaka, H., Nakazawa, T., Hayashi, N., Saura, R., Kitamura, N., Kumagai, S. Br. J. Pharmacol. (2002) [Pubmed]
  20. Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. Szkotak, A.J., Ng, A.M., Man, S.F., Baldwin, S.A., Cass, C.E., Young, J.D., Duszyk, M. J. Membr. Biol. (2003) [Pubmed]
  21. Local regulation of cystic fibrosis transmembrane regulator and epithelial sodium channel in airway epithelium. Huang, P., Gilmore, E., Kultgen, P., Barnes, P., Milgram, S., Stutts, M.J. Proceedings of the American Thoracic Society. (2004) [Pubmed]
  22. Transfer of Chinese hamster chromosome 1 to mouse cells and regional assignment of 7 genes: a combination of gene transfer and microcell fusion. Dhar, V., Searle, B.M., Athwal, R.S. Somat. Cell Mol. Genet. (1984) [Pubmed]
  23. Structure of human adenosine kinase at 1.5 A resolution. Mathews, I.I., Erion, M.D., Ealick, S.E. Biochemistry (1998) [Pubmed]
  24. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. Witczak, O., Skålhegg, B.S., Keryer, G., Bornens, M., Taskén, K., Jahnsen, T., Orstavik, S. EMBO J. (1999) [Pubmed]
  25. Biophysical properties and microfilament assembly in neutrophils: modulation by cyclic AMP. Downey, G.P., Elson, E.L., Schwab, B., Erzurum, S.C., Young, S.K., Worthen, G.S. J. Cell Biol. (1991) [Pubmed]
WikiGenes - Universities