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Gene Review

RHBDF1  -  rhomboid 5 homolog 1 (Drosophila)

Homo sapiens

Synonyms: C16orf8, DIST1, Dist1, EGFR-RS, Epidermal growth factor receptor-related protein, ...
 
 
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Disease relevance of RHBDF1

  • We measured distance refractive error (Dist R), dark refractive error (Dark R), and cycloplegic refractive error (Cyclo R) in 196 subjects whose ages ranged from 4 to 17 years, using the Canon Autoref R-1 [1].
  • Endoscopic biopsies were taken from the gastric antral mucosa, in 150 cases of non-ulcerative dyspepsia at the Gastroscopic Clinic, Dist. Hospital, Belgaum [2].
 

Psychiatry related information on RHBDF1

  • Nerv. Ment. Dist., 165: 288-293, 1977) described all patients court committed to an acute urban mental health facility in St [3].
 

High impact information on RHBDF1

  • This rhomboid, named p100(hRho) or RHBDF1, is a seven-transmembrane protein with a long N-terminal cytoplasmic extension that comprises half of the polypeptide sequence, and is found in the endoplasmic reticulum and Golgi, but not on the cell surface [4].
  • In addition, the hDist1 gene is exactly localized 1.9 kb from the hMPG gene [5].
  • Complementary DNA sequences of 250 bp and 2.5 kb from Mid1 (coordinate -68) and Dist1 (coordinate -90 to -99), respectively, were isolated from human and mouse [6].
  • The deduced partial amino acid sequences of these cDNAs are 81% and 95% identical for the Mid1 and Dist1 gene respectively [6].
  • The addition of another minor groove binder, dist A (Dist), dramatically modulate the site of DNA alkylation by Duo with great acceleration of the reaction rate [7].
 

Analytical, diagnostic and therapeutic context of RHBDF1

  • Health survey in village: Bokud Jalgaon Block Paithan, Dist: Aurangabad-report II [8].
  • In a 1989 Indiana case, Planned Parenthood of Northwest Indiana, Inc. v. Vines 543 N.E. 2d 654 (Ind. App. 3 Dist. 1989), a patient and her husband sued a clinic and a nurse for negligence in the insertion of an intrauterine device [9].
  • Long-term care. Agreement to arbitrate disputes may be unenforceable if it contravenes remedial rights. Romano v. Manor Care, Inc., 861 So. 2d 59 (Ct. App. 4th Dist. 2003) [10].

References

  1. Relation between the dark focus of accommodation and refractive error--a cycloplegic study. Miwa, T., Tokoro, T. Optometry and vision science : official publication of the American Academy of Optometry. (1993) [Pubmed]
  2. Prevalence of Campylobacter pylori in non-ulcerative dyspepsia. Ahmed, N., Malur, P.R., Sankapal, M.N., Nagalotimath, S.J. Indian journal of pathology & microbiology. (1991) [Pubmed]
  3. Who are the "committed?" Update. Mahler, H., Co, B.T. J. Nerv. Ment. Dis. (1984) [Pubmed]
  4. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Nakagawa, T., Guichard, A., Castro, C.P., Xiao, Y., Rizen, M., Zhang, H.Z., Hu, D., Bang, A., Helms, J., Bier, E., Derynck, R. Dev. Dyn. (2005) [Pubmed]
  5. Characterization and comparison of the human and mouse Dist1/alpha-globin complex reveals a tightly packed multiple gene cluster containing differentially expressed transcription units. Kielman, M.F., Smits, R., Hof, I., Bernini, L.F. Genomics (1996) [Pubmed]
  6. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. Kielman, M.F., Smits, R., Devi, T.S., Fodde, R., Bernini, L.F. Mamm. Genome (1993) [Pubmed]
  7. Cooperative alkylation by duocarmycin A-distamycin A heterodimer. Ozeki, Y., Sugiyama, H., Saito, I. Nucleic Acids Symp. Ser. (1997) [Pubmed]
  8. Health survey in village: Bokud Jalgaon Block Paithan, Dist: Aurangabad-report II. Deotal, P.G., Sathe, P.V., Nimale, N.E. Indian journal of public health. (1981) [Pubmed]
  9. Standard of care. Phillips, E. The Canadian nurse. (1995) [Pubmed]
  10. Long-term care. Agreement to arbitrate disputes may be unenforceable if it contravenes remedial rights. Romano v. Manor Care, Inc., 861 So. 2d 59 (Ct. App. 4th Dist. 2003). West, J.C. Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management. (2004) [Pubmed]
 
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