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Gene Review

Rhbdf1  -  rhomboid family 1 (Drosophila)

Mus musculus

Synonyms: C16ORF8, Dist, Dist1, Egfr-rs, Epidermal growth factor receptor-related protein, ...
 
 
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Disease relevance of Rhbdf1

  • In contrast, LPS-treated C57BL/6 NOS2-deficient (NOS2-/-) mice did not benefit from the protective effect of Dist A on mortality from endotoxemia [1].
  • Treatment with Dist A resulted in protection from hypotension in LPS-treated WT mice, but not in NOS2-/- mice [1].
 

High impact information on Rhbdf1

  • Furthermore, LPS-induced NOS2 expression was attenuated in vivo (WT murine tissues) and in vitro (primary peritoneal and RAW 264.7 murine macrophages) with addition of Dist A [1].
  • Therefore, we hypothesized that Dist A would attenuate NOS2 up-regulation in vivo during endotoxemia and improve animal survival [1].
  • Dist A selectively decreased IFN regulatory factor-1 DNA binding in the enhancer region of the NOS2 promoter, and this IFN regulatory factor-1 site is critical for the effect of Dist A in attenuating LPS induction of NOS2 [1].
  • Distamycin A (Dist A) belongs to a class of drugs termed minor-groove DNA binders, which can inhibit transcription factor binding to AT-rich regions of DNA [1].
  • Characterization and comparison of the human and mouse Dist1/alpha-globin complex reveals a tightly packed multiple gene cluster containing differentially expressed transcription units [2].

References

  1. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. Baron, R.M., Carvajal, I.M., Liu, X., Okabe, R.O., Fredenburgh, L.E., Macias, A.A., Chen, Y.H., Ejima, K., Layne, M.D., Perrella, M.A. J. Immunol. (2004) [Pubmed]
  2. Characterization and comparison of the human and mouse Dist1/alpha-globin complex reveals a tightly packed multiple gene cluster containing differentially expressed transcription units. Kielman, M.F., Smits, R., Hof, I., Bernini, L.F. Genomics (1996) [Pubmed]
 
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