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Gene Review

HHIP  -  hedgehog interacting protein

Homo sapiens

Synonyms: FLJ20992, HIP, Hedgehog-interacting protein, UNQ5825/PRO19644
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Disease relevance of HHIP


High impact information on HHIP


Biological context of HHIP


Anatomical context of HHIP

  • HHIP expression could be restored in methylated cell lines using epigenetic modifier drugs [2].

Physical interactions of HHIP

  • The crystal structures of human HHIP alone and bound to Sonic hedgehog (SHH) now reveal that HHIP is comprised of two EGF domains and a six-bladed beta-propeller domain [7].


  1. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review). Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  2. Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Martin, S.T., Sato, N., Dhara, S., Chang, R., Hustinx, S.R., Abe, T., Maitra, A., Goggins, M. Cancer Biol. Ther. (2005) [Pubmed]
  3. Expression of hedgehog proteins in the human thymus. Sacedón, R., Varas, A., Hernández-López, C., Gutiérrez-deFrías, C., Crompton, T., Zapata, A.G., Vicente, A. J. Histochem. Cytochem. (2003) [Pubmed]
  4. Molecular mechanisms of holoprosencephaly. Wallis, D.E., Muenke, M. Mol. Genet. Metab. (1999) [Pubmed]
  5. Comparative genomics on HHIP family orthologs. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  6. The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. Bak, M., Hansen, C., Friis Henriksen, K., Tommerup, N. Cytogenet. Cell Genet. (2001) [Pubmed]
  7. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Bosanac, I., Maun, H.R., Scales, S.J., Wen, X., Lingel, A., Bazan, J.F., de Sauvage, F.J., Hymowitz, S.G., Lazarus, R.A. Nat. Struct. Mol. Biol. (2009) [Pubmed]
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