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Gene Review:

s1pr1 - sphingosine-1-phosphate receptor 1

Danio rerio

Synonyms: S1P receptor 1, S1P receptor Edg-1, S1P1, SO:0000704, Sphingosine 1-phosphate receptor 1, ...

Matsui, T. et al., Im, D.S. et al.

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High impact information on edg1

Zebrafish edg1 is expressed in embryonic brain, particularly ventral diencephalon, optic stalks, and anterior hindbrain [1].
Our study reveals novel functional links between sphingosine-1-phosphate receptor signaling and cell-fibronectin interaction in the control of myocardial migration during zebrafish heart organogenesis [2].
The zebrafish mutation miles-apart (mil), which affects the gene encoding a sphingosine-1-phosphate receptor, is characterized by defective migration of myocardial precursor cells and results in the formation of two laterally positioned hearts, a condition known as cardia bifida [2].

References

Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. Im, D.S., Ungar, A.R., Lynch, K.R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., Belmonte, J.C. Nature clinical practice. Cardiovascular medicine (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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