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Gene Review

S1PR1  -  sphingosine-1-phosphate receptor 1

Bos taurus

Synonyms: EDG1, S1P1
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Disease relevance of EDG1

  • Taken together, these results indicate that LPA potently activates eNOS in BAEC in a pathway distinct from the EDG-1 receptor, but mediated by a similar receptor-mediated pathway dependent on pertussis toxin-sensitive G proteins and involving activation of the PI3-K/Akt pathway [1].

High impact information on EDG1

  • VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors [2].
  • Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that binds to S1P1 (EDG-1) receptors and activates the endothelial isoform of NO synthase (eNOS) [2].
  • S1P1 induction by VEGF was attenuated by the tyrosine kinase inhibitor genistein and by the PKC inhibitor calphostin C [2].
  • Taken together, these data indicate that VEGF specifically induces expression of S1P1 receptors, associated with enhanced intracellular signaling responses to S1P and the potentiation of S1P-mediated vasorelaxation [2].
  • S1P1 up-regulation by VEGF was seen within 30 min of VEGF addition and reached a maximum after 1.5 h [2].

Biological context of EDG1


Anatomical context of EDG1

  • We suggest that VEGF acts to sensitize the vascular endothelium to the effects of lipid mediators by promoting the induction of S1P1 receptors, representing a potentially important point of cross-talk between receptor-regulated eNOS signaling pathways in the vasculature [2].


  1. Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase. Kou, R., Igarashi, J., Michel, T. Biochemistry (2002) [Pubmed]
  2. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Igarashi, J., Erwin, P.A., Dantas, A.P., Chen, H., Michel, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. Morales-Ruiz, M., Lee, M.J., Zöllner, S., Gratton, J.P., Scotland, R., Shiojima, I., Walsh, K., Hla, T., Sessa, W.C. J. Biol. Chem. (2001) [Pubmed]
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