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Gene Review

S1pr1  -  sphingosine-1-phosphate receptor 1

Mus musculus

Synonyms: AI849002, Edg1, Endothelial differentiation G-protein coupled receptor 1, Lpb1, Lysophospholipid receptor B1, ...
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Disease relevance of Edg1


High impact information on Edg1


Chemical compound and disease context of Edg1


Biological context of Edg1


Anatomical context of Edg1


Associations of Edg1 with chemical compounds


Regulatory relationships of Edg1


Other interactions of Edg1


Analytical, diagnostic and therapeutic context of Edg1


  1. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C.X., Hobson, J.P., Rosenfeldt, H.M., Nava, V.E., Chae, S.S., Lee, M.J., Liu, C.H., Hla, T., Spiegel, S., Proia, R.L. J. Clin. Invest. (2000) [Pubmed]
  2. Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. Yamaguchi, H., Kitayama, J., Takuwa, N., Arikawa, K., Inoki, I., Takehara, K., Nagawa, H., Takuwa, Y. Biochem. J. (2003) [Pubmed]
  3. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Chae, S.S., Paik, J.H., Allende, M.L., Proia, R.L., Hla, T. Dev. Biol. (2004) [Pubmed]
  4. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. Van Brocklyn, J.R., Lee, M.J., Menzeleev, R., Olivera, A., Edsall, L., Cuvillier, O., Thomas, D.M., Coopman, P.J., Thangada, S., Liu, C.H., Hla, T., Spiegel, S. J. Cell Biol. (1998) [Pubmed]
  5. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Hobson, J.P., Rosenfeldt, H.M., Barak, L.S., Olivera, A., Poulton, S., Caron, M.G., Milstien, S., Spiegel, S. Science (2001) [Pubmed]
  6. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Paik, J.H., Skoura, A., Chae, S.S., Cowan, A.E., Han, D.K., Proia, R.L., Hla, T. Genes Dev. (2004) [Pubmed]
  7. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Cinamon, G., Matloubian, M., Lesneski, M.J., Xu, Y., Low, C., Lu, T., Proia, R.L., Cyster, J.G. Nat. Immunol. (2004) [Pubmed]
  8. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Kataoka, H., Sugahara, K., Shimano, K., Teshima, K., Koyama, M., Fukunari, A., Chiba, K. Cell. Mol. Immunol. (2005) [Pubmed]
  9. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Sugimoto, N., Takuwa, N., Okamoto, H., Sakurada, S., Takuwa, Y. Mol. Cell. Biol. (2003) [Pubmed]
  10. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. Sanna, M.G., Liao, J., Jo, E., Alfonso, C., Ahn, M.Y., Peterson, M.S., Webb, B., Lefebvre, S., Chun, J., Gray, N., Rosen, H. J. Biol. Chem. (2004) [Pubmed]
  11. Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. Jolly, P.S., Bektas, M., Olivera, A., Gonzalez-Espinosa, C., Proia, R.L., Rivera, J., Milstien, S., Spiegel, S. J. Exp. Med. (2004) [Pubmed]
  12. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. Chae, S.S., Paik, J.H., Furneaux, H., Hla, T. J. Clin. Invest. (2004) [Pubmed]
  13. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Allende, M.L., Yamashita, T., Proia, R.L. Blood (2003) [Pubmed]
  14. Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. Kohno, T., Igarashi, Y. J. Biochem. (2003) [Pubmed]
  15. Sphingosine-1 Phosphate Prevents Monocyte/Endothelial Interactions in Type 1 Diabetic NOD Mice Through Activation of the S1P1 Receptor. Whetzel, A.M., Bolick, D.T., Srinivasan, S., Macdonald, T.L., Morris, M.A., Ley, K., Hedrick, C.C. Circ. Res. (2006) [Pubmed]
  16. The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. Sawicka, E., Dubois, G., Jarai, G., Edwards, M., Thomas, M., Nicholls, A., Albert, R., Newson, C., Brinkmann, V., Walker, C. J. Immunol. (2005) [Pubmed]
  17. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. Kono, M., Mi, Y., Liu, Y., Sasaki, T., Allende, M.L., Wu, Y.P., Yamashita, T., Proia, R.L. J. Biol. Chem. (2004) [Pubmed]
  18. In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Yang, A.H., Ishii, I., Chun, J. Biochim. Biophys. Acta (2002) [Pubmed]
  19. Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. Graeler, M.H., Kong, Y., Karliner, J.S., Goetzl, E.J. J. Biol. Chem. (2003) [Pubmed]
  20. Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. Fieger, C.B., Huang, M.C., Van Brocklyn, J.R., Goetzl, E.J. FASEB J. (2005) [Pubmed]
  21. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. Means, C.K., Miyamoto, S., Chun, J., Brown, J.H. J. Biol. Chem. (2008) [Pubmed]
  22. FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments. Yopp, A.C., Fu, S., Honig, S.M., Randolph, G.J., Ding, Y., Krieger, N.R., Bromberg, J.S. J. Immunol. (2004) [Pubmed]
  23. Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. Ochando, J.C., Yopp, A.C., Yang, Y., Garin, A., Li, Y., Boros, P., Llodra, J., Ding, Y., Lira, S.A., Krieger, N.R., Bromberg, J.S. J. Immunol. (2005) [Pubmed]
  24. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Pham, T.H., Okada, T., Matloubian, M., Lo, C.G., Cyster, J.G. Immunity (2008) [Pubmed]
  25. Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. Sawicka, E., Zuany-Amorim, C., Manlius, C., Trifilieff, A., Brinkmann, V., Kemeny, D.M., Walker, C. J. Immunol. (2003) [Pubmed]
  26. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. McGiffert, C., Contos, J.J., Friedman, B., Chun, J. FEBS Lett. (2002) [Pubmed]
  27. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Matloubian, M., Lo, C.G., Cinamon, G., Lesneski, M.J., Xu, Y., Brinkmann, V., Allende, M.L., Proia, R.L., Cyster, J.G. Nature (2004) [Pubmed]
  28. Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells. Krump-Konvalinkova, V., Yasuda, S., Rubic, T., Makarova, N., Mages, J., Erl, W., Vosseler, C., Kirkpatrick, C.J., Tigyi, G., Siess, W. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  29. Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection. Habicht, A., Clarkson, M.R., Yang, J., Henderson, J., Brinkmann, V., Fernandes, S., Jurewicz, M., Yuan, X., Sayegh, M.H. J. Immunol. (2006) [Pubmed]
  30. Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. Singer, I.I., Tian, M., Wickham, L.A., Lin, J., Matheravidathu, S.S., Forrest, M.J., Mandala, S., Quackenbush, E.J. J. Immunol. (2005) [Pubmed]
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