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Gene Review

Nppa  -  natriuretic peptide A

Rattus norvegicus

Synonyms: ANF, ANP, Natriuretic peptides A, Pnd, Prepronatriodilatin, ...
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Disease relevance of Nppa


Psychiatry related information on Nppa

  • Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP-binding sites [4].
  • Atrial natriuretic factor (ANF) and its smaller congeners are produced and released from rat brains to regulate the cardiovascular system, drinking behavior, and neurohormone release at the central level [5].
  • ANP in doses of 200 and 500 ng/rat induced significant anxiolysis, comparable with that of lorazepam (0.5 mg/kg, i.p.) in a variety of anxiety models (open-field, elevated plus-maze, social interaction, and novelty-induced feeding suppression tests) [6].
  • 1. The influence of progesterone on the activity of atrial natriuretic factor (ANF) on rat myometrial motor activity was determined in vitro [7].
  • Finally, ANP had no effect on eating or drinking after food deprivation, suggesting that the rats in the other experiments were not acutely incapacitated [8].

High impact information on Nppa


Chemical compound and disease context of Nppa


Biological context of Nppa


Anatomical context of Nppa


Associations of Nppa with chemical compounds

  • Estrogen receptors activate atrial natriuretic peptide in the rat heart [2].
  • The effects of ANP were mimicked by 8-bromo-guanosine 3', 5'-cyclic monophosphate (cGMP) and were associated with the activation of cGMP-dependent kinase (cGK), suggesting the involvement of guanylate cyclase-coupled natriuretic peptide receptor (NPR)-A/B ANP receptors [3].
  • The p38 MAPK inhibitor SB203580 abolished ANP protection by reverting p38 MAPK-mediated regulation of Na(+) influx by the Na(+)/H(+) exchanger [3].
  • In addition, angiotensin II- (Ang II-) mediated inhibition of adenylyl cyclase ( approximately 30%) was also abolished by C-ANP(4-23) treatment, indicating that the desensitization elicited by ANP was heterologous [18].
  • Atrial natriuretic peptide (ANP) receptors A and B are guanylyl cyclase receptors, whereas ANP-C receptors are coupled to adenylyl cyclase through inhibitory guanine nucleotide (Gi) protein [18].

Physical interactions of Nppa


Regulatory relationships of Nppa


Other interactions of Nppa

  • ANP is not amidated by PAM, but rather is processed to its active form (amino acids 99-126) by the proteolytic cleavage of pro-ANP [20].
  • Reciprocal paracrine pathways link atrial natriuretic peptide and somatostatin secretion in the antrum of the stomach [31].
  • In cardiomyocytes, a distinct increase in ANP positivity was found, whereas PCNA positivity was very low [32].
  • There was no correlation between the Nppa or Nppb genes or other markers in this region and either heart weight or left ventricular weight in F2 rats [1].
  • Staurosporine and chelerythrine, protein kinase C (PKC) inhibitors at 1 and 100 nm, respectively, prevented the AngII-mediated desensitization of C-ANF 4-23-sensitive adenylyl cyclase [33].

Analytical, diagnostic and therapeutic context of Nppa


  1. Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat. Ye, P., West, M.J. Clin. Exp. Pharmacol. Physiol. (2003) [Pubmed]
  2. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Jankowski, M., Rachelska, G., Donghao, W., McCann, S.M., Gutkowska, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Mechanisms of hepatocyte protection against hypoxic injury by atrial natriuretic peptide. Carini, R., De Cesaris, M.G., Splendore, R., Domenicotti, C., Nitti, M.P., Pronzato, M.A., Albano, E. Hepatology (2003) [Pubmed]
  4. Effects of dehydration on endocrine regulation of the electrolyte and fluid balance and atrial natriuretic peptide-binding sites in perinatally malnourished adult male rats. Sebaai, N., Lesage, J., Alaoui, A., Dupouy, J.P., Deloof, S. Eur. J. Endocrinol. (2002) [Pubmed]
  5. D1 receptors mediate dopamine stimulation of immunoreactive atrial natriuretic factor (ANF) release and pro-ANF messenger ribonucleic acid expression of rat hypothalamic neurons in culture. Lee, D., Huang, W., Lim, A.T. Endocrinology (1995) [Pubmed]
  6. Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat. Bhattacharya, S.K., Chakrabarti, A., Sandler, M., Glover, V. Neuropsychopharmacology (1996) [Pubmed]
  7. Inhibition of the tocolytic activity of atrial natriuretic factor by progesterone and potentiation by progesterone receptor antagonist RU486 in rats. Potvin, W., Mulay, S., Varma, D.R. Br. J. Pharmacol. (1991) [Pubmed]
  8. Atrial natriuretic peptide in the subfornical organ reduces drinking induced by angiotensin or in response to water deprivation. Ehrlich, K.J., Fitts, D.A. Behav. Neurosci. (1990) [Pubmed]
  9. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng, Y., Rapp, J.P. Nat. Genet. (1992) [Pubmed]
  10. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Schulz, S., Singh, S., Bellet, R.A., Singh, G., Tubb, D.J., Chin, H., Garbers, D.L. Cell (1989) [Pubmed]
  11. Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways. Bloch, K.D., Seidman, J.G., Naftilan, J.D., Fallon, J.T., Seidman, C.E. Cell (1986) [Pubmed]
  12. Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase. Light, D.B., Corbin, J.D., Stanton, B.A. Nature (1990) [Pubmed]
  13. Inhibition of the firing of vasopressin neurons by atriopeptin. Standaert, D.G., Cechetto, D.F., Needleman, P., Saper, C.B. Nature (1987) [Pubmed]
  14. Atrial natriuretic peptide regulation of noradrenaline release in the anterior hypothalamic area of spontaneously hypertensive rats. Peng, N., Oparil, S., Meng, Q.C., Wyss, J.M. J. Clin. Invest. (1996) [Pubmed]
  15. Effect of angiotensin II blockade on the fibroproliferative response to phenylephrine in the rat heart. Farivar, R.S., Crawford, D.C., Chobanian, A.V., Brecher, P. Hypertension (1995) [Pubmed]
  16. Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland. Shimomura, H., Nashida, T., Imai, A. Mol. Cell. Biochem. (1994) [Pubmed]
  17. Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein. Paul, A.K., Marala, R.B., Jaiswal, R.K., Sharma, R.K. Science (1987) [Pubmed]
  18. Downregulation of atrial natriuretic peptide ANP-C receptor is associated with alterations in G-protein expression in A10 smooth muscle cells. Anand-Srivastava, M.B. Biochemistry (2000) [Pubmed]
  19. Inhibition of atrial natriuretic peptide (ANP) C receptor expression by antisense oligodeoxynucleotides in A10 vascular smooth-muscle cells is associated with attenuation of ANP-C-receptor-mediated inhibition of adenylyl cyclase. Palaparti, A., Li, Y., Anand-Srivastava, M.B. Biochem. J. (2000) [Pubmed]
  20. Peptidylglycine-alpha-amidating monooxygenase and pro-atrial natriuretic peptide constitute the major membrane-associated proteins of rat atrial secretory granules. O'Donnell, P.J., Driscoll, W.J., Bäck, N., Muth, E., Mueller, G.P. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  21. Characteristics of ANP-binding sites in the adrenal capsules of term-pregnant rats. Forcier, I., St-Louis, J., Brochu, M. Mol. Cell. Endocrinol. (1996) [Pubmed]
  22. Regulation of natriuretic peptide receptors by thyrotropin in FRTL-5 rat thyroid cells: evidence for nonguanylate cyclase atrial natriuretic factor-binding sites in cells lacking the natriuretic peptide receptor C. Sellitti, D.F., Doi, S.Q. Endocrinology (1999) [Pubmed]
  23. Identification and characterization of atrial natriuretic factor receptors in the rat retina. Fernandez-Durango, R., Sanchez, D., Gutkowska, J., Carrier, F., Fernandez-Cruz, A. Life Sci. (1989) [Pubmed]
  24. Cross-linking of atrial natriuretic peptide to binding sites in rat olfactory bulb membranes. Wildey, G.M., Glembotski, C.C. J. Neurosci. (1986) [Pubmed]
  25. Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression. Zang, M.X., Li, Y., Wang, H., Wang, J.B., Jia, H.T. J. Biol. Chem. (2004) [Pubmed]
  26. Natriuretic peptide receptors mediate different responses in rat renal microvessels. Endlich, K., Steinhausen, M. Kidney Int. (1997) [Pubmed]
  27. Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Murakami, Y., Kato, Y., Tojo, K., Inoue, T., Yanaihara, N., Imura, H. Endocrinology (1988) [Pubmed]
  28. Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes. Wu, L., Zhao, L., Zheng, Q., Shang, F., Wang, X., Wang, L., Lang, B. Mol. Cell. Biochem. (2006) [Pubmed]
  29. Corticotropin-releasing hormone causes antidiuresis and antinatriuresis by stimulating vasopressin and inhibiting atrial natriuretic peptide release in male rats. Gutkowska, J., Jankowski, M., Mukaddam-Daher, S., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  30. Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor. Potential role in the inhibition of astrocyte proliferation. Prins, B.A., Weber, M.J., Hu, R.M., Pedram, A., Daniels, M., Levin, E.R. J. Biol. Chem. (1996) [Pubmed]
  31. Reciprocal paracrine pathways link atrial natriuretic peptide and somatostatin secretion in the antrum of the stomach. Gower, W.R., McCuen, R.W., Arimura, A., Coy, D.A., Dietz, J.R., Landon, C.S., Schubert, M.L. Regul. Pept. (2003) [Pubmed]
  32. Distribution patterns of PCNA and ANP in perinatal stages of the developing rat heart. Cayli, S., Ustünel, I., Celik-Ozenci, C., Korgun, E.T., Demir, R. Acta Histochem. (2002) [Pubmed]
  33. Angiotensin II modulates ANP-R2/ANP-C receptor-mediated inhibition of adenylyl cyclase in vascular smooth muscle cells: role of protein kinase C. Palaparti, A., Anand-Srivastava, M.B. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  34. Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat. Rollín, R., Mediero, A., Fernández-Cruz, A., Fernández-Durango, R. Mol. Vis. (2005) [Pubmed]
  35. The expression of atrial natriuretic peptide in the oviduct and its functions in pig spermatozoa. Zhang, M., Hong, H., Zhou, B., Jin, S., Wang, C., Fu, M., Wang, S., Xia, G. J. Endocrinol. (2006) [Pubmed]
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