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Gene Review:

SPANXC - SPANX family, member C

Homo sapiens

Synonyms: CT11.3, CTp11, Cancer/testis antigen 11.3, Cancer/testis-associated protein CTp11, Nuclear-associated protein SPAN-Xc, ...

Goydos, J.S. et al., Westbrook, V.A. et al., Baffoe-Bonnie, A.B. et al., Zendman, A.J. et al.

Zendman, Cornelissen, Weidle, Ruiter, van Muijen,

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Disease relevance of SPANXC

CTp11, a novel member of the family of human cancer/testis antigens [1].
One CT antigen, CTp11, was shown to be expressed by metastasizing melanoma cell lines but not by nonmetastasizing variants [2].

High impact information on SPANXC

The two transcription units mapping within this interval are the LDOC1 and SPANXC genes [3].
Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa [4].
In this paper, we identify homology of the CTA CTp11 with SPAN-X (sperm protein associated with the nucleus mapped to the X chromosome) [4].
CTp11 tended to be expressed by primary melanomas and NY-ESO-1 by metastatic samples (P < 0.02) [2].

Other interactions of SPANXC

NY-ESO-1 may be a marker of more advanced disease and CTp11 of less advanced disease [2].

References

CTp11, a novel member of the family of human cancer/testis antigens. Zendman, A.J., Cornelissen, I.M., Weidle, U.H., Ruiter, D.J., van Muijen, G.N. Cancer Res. (1999) [Pubmed]
NY-ESO-1 and CTp11 expression may correlate with stage of progression in melanoma. Goydos, J.S., Patel, M., Shih, W. J. Surg. Res. (2001) [Pubmed]
A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. Baffoe-Bonnie, A.B., Smith, J.R., Stephan, D.A., Schleutker, J., Carpten, J.D., Kainu, T., Gillanders, E.M., Matikainen, M., Teslovich, T.M., Tammela, T., Sood, R., Balshem, A.M., Scarborough, S.D., Xu, J., Isaacs, W.B., Trent, J.M., Kallioniemi, O.P., Bailey-Wilson, J.E. Hum. Genet. (2005) [Pubmed]
Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. Westbrook, V.A., Diekman, A.B., Naaby-Hansen, S., Coonrod, S.A., Klotz, K.L., Thomas, T.S., Norton, E.J., Flickinger, C.J., Herr, J.C. Biol. Reprod. (2001) [Pubmed]

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