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Gene Review

LDOC1  -  leucine zipper, down-regulated in cancer 1

Homo sapiens

Synonyms: BCUR1, Leucine zipper protein down-regulated in cancer cells, Mar7, Mart7, Protein LDOC1
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Disease relevance of LDOC1


High impact information on LDOC1


Biological context of LDOC1

  • Here, we found that overexpression of LDOC1 caused externalization of the cell membrane phosphatidylserine, which was characteristic for early-phase apoptotic events, and reduced cell viability in some human cell lines [2].
  • Although the function of LDOC1 is still unknown, our results suggest that this novel gene codes for a nuclear protein, and down-regulation of LDOC1 may have an important role in the development and/or progression of some cancers [5].
  • OBJECTIVES: To estimate excess lifetime risk of (a) mortality from lung disease other than cancer (LDOC), and, (b) onset of radiographic silicosis, arising from occupational exposure to respirable crystalline silica dust [3].

Regulatory relationships of LDOC1

  • The activation of NF-kappaB through ligand-induced stimulation by tumor necrosis factor-alpha (TNF-alpha) or phorbol 12-myristate 13-acetate (PMA) was also inhibited by transient expression of LDOC1 in a dose dependent manner [1].


  1. Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. Nagasaki, K., Schem, C., von Kaisenberg, C., Biallek, M., Rösel, F., Jonat, W., Maass, N. Int. J. Cancer (2003) [Pubmed]
  2. LDOC1, a novel MZF-1-interacting protein, induces apoptosis. Inoue, M., Takahashi, K., Niide, O., Shibata, M., Fukuzawa, M., Ra, C. FEBS Lett. (2005) [Pubmed]
  3. Exposure to crystalline silica, silicosis, and lung disease other than cancer in diatomaceous earth industry workers: a quantitative risk assessment. Park, R., Rice, F., Stayner, L., Smith, R., Gilbert, S., Checkoway, H. Occupational and environmental medicine. (2002) [Pubmed]
  4. A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. Baffoe-Bonnie, A.B., Smith, J.R., Stephan, D.A., Schleutker, J., Carpten, J.D., Kainu, T., Gillanders, E.M., Matikainen, M., Teslovich, T.M., Tammela, T., Sood, R., Balshem, A.M., Scarborough, S.D., Xu, J., Isaacs, W.B., Trent, J.M., Kallioniemi, O.P., Bailey-Wilson, J.E. Hum. Genet. (2005) [Pubmed]
  5. Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. Nagasaki, K., Manabe, T., Hanzawa, H., Maass, N., Tsukada, T., Yamaguchi, K. Cancer Lett. (1999) [Pubmed]
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