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Gene Review

SPANXA1  -  sperm protein associated with the nucleus,...

Homo sapiens

Synonyms: CT11.1, NAP-X, SPAN-X, SPAN-Xa, SPAN-Xb, ...
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Disease relevance of SPANXA1


Psychiatry related information on SPANXA1

  • The non-dominant (left) hand movements of three groups of participants were examined: 10 individuals with limb-apraxia (APX); 8 individuals without limb apraxia who had sustained a LCVA (NAPX); and 19 healthy individuals without a history of brain impairment (NBD) [2].

High impact information on SPANXA1


Biological context of SPANXA1


Anatomical context of SPANXA1

  • In this study, RT-PCR of human testis mRNA from individuals showed that, although all SPANXA/D genes are expressed in humans, differences are evident [4].
  • The SPANXa/d protein localized to the nuclear envelope of round, condensing and elongating spermatids, specifically to regions that do not underlie the developing acrosome [4].

Associations of SPANXA1 with chemical compounds


Other interactions of SPANXA1


Analytical, diagnostic and therapeutic context of SPANXA1


  1. Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies. Wang, Z., Zhang, Y., Liu, H., Salati, E., Chiriva-Internati, M., Lim, S.H. Blood (2003) [Pubmed]
  2. The significance of clumsy gestures in apraxia following a left hemisphere stroke. Kangas, M., Tate, R.L. Neuropsychological rehabilitation. (2006) [Pubmed]
  3. SPAN-Xb expression in myeloma cells is dependent on promoter hypomethylation and can be upregulated pharmacologically. Wang, Z., Zhang, J., Zhang, Y., Lim, S.H. Int. J. Cancer (2006) [Pubmed]
  4. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook, V.A., Schoppee, P.D., Vanage, G.R., Klotz, K.L., Diekman, A.B., Flickinger, C.J., Coppola, M.A., Herr, J.C. Mol. Hum. Reprod. (2006) [Pubmed]
  5. SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein. Wang, Z., Zhang, J., Zhang, Y., Srivenugopal, K.S., Lim, S.H. Int. J. Cancer (2006) [Pubmed]
  6. Pattern of gene expression and immune responses to Semenogelin 1 in chronic hematologic malignancies. Zhang, Y., Wang, Z., Liu, H., Giles, F.J., Lim, S.H. J. Immunother. (2003) [Pubmed]
  7. Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. Westbrook, V.A., Diekman, A.B., Naaby-Hansen, S., Coonrod, S.A., Klotz, K.L., Thomas, T.S., Norton, E.J., Flickinger, C.J., Herr, J.C. Biol. Reprod. (2001) [Pubmed]
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