The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

ST3GAL2  -  ST3 beta-galactoside alpha-2,3...

Homo sapiens

Synonyms: Alpha 2,3-ST 2, Beta-galactoside alpha-2,3-sialyltransferase 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ST3GAL2

  • A multiplex reverse transcription-PCR method was used here to determine the expression of five sialyltransferases (ST3Gal III, ST6Gal I, ST3Gal IV, ST3Gal I, and ST3Gal II) in 49 patients surgically treated for locoregional breast cancer [1].
 

High impact information on ST3GAL2

  • Expression of alpha2,3-sialyltransferases ST3Gal-I, ST3Gal-II, and enzyme activity of alpha2,3-sialyltransferase was significantly increased (P < 0.001) in carcinoma specimens compared with normal mucosa [2].
  • The presence of TF was not altered by transfection of the cells with either sialyltransferase ST3Gal-I or ST3Gal-II [2].
  • Transient transfection of COS-7 and ACHN cells with this cDNA induced an increase of MSGb5, whereas stable transfection of antisense ST3Gal II cDNA suppressed expression of MSGb5 in ACHN cells [3].
  • The ST3Gal II mRNA level was increased in 7 of 8 RCC cell lines and in all six RCC tissues surgically obtained, although it was not necessarily consistent with the MSGb5 level in RCC cell lines [3].
  • Two of the twelve glycosyltransferase genes, Fuc-TIV and ST3Gal II, were significantly up-regulated in all cancerous tissues regardless of the histologic features [4].
 

Associations of ST3GAL2 with chemical compounds

  • Estradiol induced a statistically significant increase in ST3Gal III and a decrease in ST6Gal I, whereas the two other enzymes, ST3Gal IV and ST3Gal I, are not modified and expression of the fifth enzyme, ST3Gal II, was very low or not detectable [5].
 

Other interactions of ST3GAL2

  • The gene symbols for these genes have been designated SIAT4A, SIAT4B and SIAT4C, respectively [6].
  • On the other hand, GeneChip analysis failed to detect any expression of GnT-III and GnT-V as well as of ST3Gal-I and ST3Gal-II, although these sequences could be amplified from the samples used for microarray analysis [7].
 

Analytical, diagnostic and therapeutic context of ST3GAL2

References

  1. Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer. Recchi, M.A., Hebbar, M., Hornez, L., Harduin-Lepers, A., Peyrat, J.P., Delannoy, P. Cancer Res. (1998) [Pubmed]
  2. Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomas. Schneider, F., Kemmner, W., Haensch, W., Franke, G., Gretschel, S., Karsten, U., Schlag, P.M. Cancer Res. (2001) [Pubmed]
  3. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. Saito, S., Aoki, H., Ito, A., Ueno, S., Wada, T., Mitsuzuka, K., Satoh, M., Arai, Y., Miyagi, T. J. Biol. Chem. (2003) [Pubmed]
  4. Up-regulation of a set of glycosyltransferase genes in human colorectal cancer. Kudo, T., Ikehara, Y., Togayachi, A., Morozumi, K., Watanabe, M., Nakamura, M., Nishihara, S., Narimatsu, H. Lab. Invest. (1998) [Pubmed]
  5. Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7. Peyrat, J.P., Recchi, M.A., Hebbar, M., Pawlowski, V., Hornez, L., Dong-Lebouhris, X., Hondermarck, H., Harduin-Lepers, A., Delannoy, P. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
  6. Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies. Chang, M.L., Eddy, R.L., Shows, T.B., Lau, J.T. Glycobiology (1995) [Pubmed]
  7. Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays. Kemmner, W., Roefzaad, C., Haensch, W., Schlag, P.M. Biochim. Biophys. Acta (2003) [Pubmed]
  8. Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients. Hebbar, M., Krzewinski-Recchi, M.A., Hornez, L., Verdière, A., Harduin-Lepers, A., Bonneterre, J., Delannoy, P., Peyrat, J.P. Int. J. Biol. Markers (2003) [Pubmed]
 
WikiGenes - Universities