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Gene Review

FUT4  -  fucosyltransferase 4 (alpha (1,3)...

Homo sapiens

Synonyms: Alpha-(1,3)-fucosyltransferase 4, CD15, ELAM-1 ligand fucosyltransferase, ELFT, FCT3A, ...
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Disease relevance of FUT4

  • The present results suggest that these elements play a critical role in the colon adenocarcinoma and leukemia cell-specific transcriptional regulation of the FUT4 gene [1].
  • These results suggest that Fuc-TIV and Fuc-TVII expression may be of prognostic value among patients with lung cancer by participating in the biosynthesis of sialyl Lewis x [2].
  • Markers associated with Hodgkin's lymphoma cells, CD15 and CD30, were also positive [3].
  • Localization of anti-Leu-M1 (CD15) binding sites in Hodgkin's disease by immunoelectron microscopic examination [4].
  • We postulate that the absence of CD15 on human glioma cells may explain, to some extent, the general failure of intrinsic brain tumours to metastasis by precluding the adhesion of circulating neoplastic glia to 'target' organ endothelium [5].

Psychiatry related information on FUT4


High impact information on FUT4


Chemical compound and disease context of FUT4


Biological context of FUT4

  • Like FUT4, this embryonic FUT9 is N-ethylmaleimide and heat resistant and the corresponding gene was confirmed to be localized in the chromosome band 6q16 [14].
  • FUT4 and FUT9 genes are expressed early in human embryogenesis [14].
  • Using mRNA from 40- to 65-day-old embryos, we have prepared different hexamer and oligo-dT cDNA libraries and cloned, by rapid amplification cDNA ends-PCR, FUT4 and FUT9 alpha3-fucosyltransferase transcripts [14].
  • The acceptor specificity and the kinetics of the alpha3-fucosyltransferase encoded by this FUT9 transcript are similar to the FUT4 enzyme, except for the utilization of the lac-di-NAc acceptor which is not efficiently transformed by the FUT9 enzyme [14].
  • Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis [15].

Anatomical context of FUT4

  • The enzyme in COS cell extracts acting on unsialylated Type 2 structures is closely similar in its properties to the alpha1,3-fucosyltransferase encoded by human FUT4 gene and does not resemble the product of the FUT5 gene [16].
  • Transcript analyses show that FUT7 and FUT4 are inversely expressed in HL60 and variant cell lines [17].
  • A myeloid enzyme is present in 5 to 10 week old human embryos and is later progressively replaced by different patterns of adult fucosyltransferase enzymes in all tissues, except in leukocytes and brain which continue to express a FUT4 like enzyme in the adult.(ABSTRACT TRUNCATED AT 250 WORDS)[18]
  • The products of the monomorphic genes FUT4 and FUT7 seem implicated in cell-cell interactions during embryo-foetal development and in the leukocyte adhesion phenomena to endothelial cells in the adult [19].
  • These findings suggest that the expression of CD15 in mature granulocytes is directed by FUT9, whereas it is determined in promyelocytes and monocytes by FUT4 [20].

Associations of FUT4 with chemical compounds


Regulatory relationships of FUT4


Other interactions of FUT4

  • The enzymes resembling the human FUT4 and FUT8 gene products both had pH optima of 7.0 and were resistant to 10 mM NEM [16].
  • FUT4 and FUT3/5/6 were found on the same chicken chromosome [26].
  • At 4 h after CPB, downregulation was observed for CD14 (P = 0.004), CD45 (P = 0.014), and CD15 (P = 0.0056) [27].
  • Commitment to monocyte differentiation, suggested by the presence of an LFA-1hi CD11c+ subset within the CD33loCD15- subpopulation, was clearly signaled by upregulation of CD33; these monocyte-lineage committed cells were exclusively CD33hi, CD44hi, CD11ahi, CD11c+, and exhibited a broad range of intensity of CD15 expression [28].
  • The leukocyte carbohydrate (CHO) Ag CD15, sialyl-CD15, and CDw65 have recently been found to function as ligands for CD62 and ELAM-1 cell adhesion molecules on platelets and endothelium, respectively [29].

Analytical, diagnostic and therapeutic context of FUT4


  1. Expression and transcriptional regulation of the human alpha1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines. Taniguchi, A., Suga, R., Matsumoto, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer. Ogawa, J., Inoue, H., Koide, S. Cancer Res. (1996) [Pubmed]
  3. Isolation and characterization of an early T-helper/inducer cell line with a unique pattern of surface phenotype, constitutive cytokine secretion and myc oncogene expression. Gazitt, Y., He, Y.J., Shults, K., Stelzer, G.T., Cohen, R.J. Leukemia (1993) [Pubmed]
  4. Localization of anti-Leu-M1 (CD15) binding sites in Hodgkin's disease by immunoelectron microscopic examination. Taatjes, D.J., Mount, S.L., Trainer, T.D., Tindle, B.H. Am. J. Clin. Pathol. (1994) [Pubmed]
  5. Nonexpression of CD15 by neoplastic glia: a barrier to metastasis? Martin, K., Akinwunmi, J., Rooprai, H.K., Kennedy, A.J., Linke, A., Ognjenovic, N., Pilkington, G.J. Anticancer Res. (1995) [Pubmed]
  6. Expression of the CD15 epitope in the human magnocellular basal forebrain system. Morres, S.A., Mai, J.K., Teckhaus, L. Histochem. J. (1992) [Pubmed]
  7. CD62/P-selectin recognition of myeloid and tumor cell sulfatides. Aruffo, A., Kolanus, W., Walz, G., Fredman, P., Seed, B. Cell (1991) [Pubmed]
  8. PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Larsen, E., Palabrica, T., Sajer, S., Gilbert, G.E., Wagner, D.D., Furie, B.C., Furie, B. Cell (1990) [Pubmed]
  9. ELFT: a gene that directs the expression of an ELAM-1 ligand. Goelz, S.E., Hession, C., Goff, D., Griffiths, B., Tizard, R., Newman, B., Chi-Rosso, G., Lobb, R. Cell (1990) [Pubmed]
  10. Differential effect of 4-hydroperoxycyclophosphamide and antimyeloid monoclonal antibodies on T and natural killer cells during bone marrow purging. Zhong, R.K., Donnenberg, A.D., Rubin, J., Ball, E.D. Blood (1994) [Pubmed]
  11. Osteomyelitis: diagnosis with (99m)Tc-labeled antigranulocyte antibodies compared with diagnosis with (111)In-labeled leukocytes--initial experience. Palestro, C.J., Kipper, S.L., Weiland, F.L., Love, C., Tomas, M.B. Radiology. (2002) [Pubmed]
  12. Renal tubular abnormalities in hydrops fetalis: a histological and immunohistochemical study. Endo, H., Oka, T. Early Hum. Dev. (1997) [Pubmed]
  13. Expression of CD15 in tumours of the nervous system. Reifenberger, G., Sieth, P., Niederhaus, M., Wechsler, W. Histochem. J. (1992) [Pubmed]
  14. FUT4 and FUT9 genes are expressed early in human embryogenesis. Cailleau-Thomas, A., Coullin, P., Candelier, J.J., Balanzino, L., Mennesson, B., Oriol, R., Mollicone, R. Glycobiology (2000) [Pubmed]
  15. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. Azuma, Y., Ito, M., Taniguchi, A., Matsumoto, K. Biochim. Biophys. Acta (2004) [Pubmed]
  16. Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase. Clarke, J.L., Watkins, W.M. Glycobiology (1999) [Pubmed]
  17. A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells. Weston, B.W., Hiller, K.M., Mayben, J.P., Manousos, G., Nelson, C.M., Klein, M.B., Goodman, J.L. Eur. J. Haematol. (1999) [Pubmed]
  18. Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). Mollicone, R., Candelier, J.J., Reguigne, I., Couillin, P., Fletcher, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1994) [Pubmed]
  19. Advances in molecular genetics of alpha-2- and alpha-3/4-fucosyltransferases. Costache, M., Cailleau, A., Fernandez-Mateos, P., Oriol, R., Mollicone, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1997) [Pubmed]
  20. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. Nakayama, F., Nishihara, S., Iwasaki, H., Kudo, T., Okubo, R., Kaneko, M., Nakamura, M., Karube, M., Sasaki, K., Narimatsu, H. J. Biol. Chem. (2001) [Pubmed]
  21. Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils. Skubitz, K.M., Snook, R.W. J. Immunol. (1987) [Pubmed]
  22. Downregulation of the selectin ligand-producing fucosyltransferases Fuc-TIV and Fuc-TVII during foam cell formation in monocyte-derived macrophages. Cullen, P., Mohr, S., Brennhausen, B., Cignarella, A., Assmann, G. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  23. CD15 monoclonal antibodies react with a phosphotyrosine-containing protein on the surface of human neutrophils. Skubitz, K.M., Mendiola, J.R., Collett, M.S. J. Immunol. (1988) [Pubmed]
  24. Cardiac valvular anomalies in Fabry disease. Clinical, morphologic, and biochemical studies. Desnick, R.J., Blieden, L.C., Sharp, H.L., Hofschire, P.J., Moller, J.H. Circulation (1976) [Pubmed]
  25. Immunophenotyping of Hodgkin's disease--an aid to its classification. Kalyan, K., Basu, D., Soundararaghavan, J. Indian journal of pathology & microbiology. (2006) [Pubmed]
  26. Cytogenetics, conserved synteny and evolution of chicken fucosyltransferase genes compared to human. Coullin, P., Crooijmans, R.P., Fillon, V., Mollicone, R., Groenen, M.A., Adrien-Dehais, C., Bernheim, A., Zoorob, R., Oriol, R., Candelier, J.J. Cytogenet. Genome Res. (2003) [Pubmed]
  27. Monitoring of monocyte functional state after extracorporeal circulation: a flow cytometry study. Sbrana, S., Parri, M.S., De Filippis, R., Gianetti, J., Clerico, A. Cytometry. Part B, Clinical cytometry. (2004) [Pubmed]
  28. Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Kansas, G.S., Muirhead, M.J., Dailey, M.O. Blood (1990) [Pubmed]
  29. Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65). Lund-Johansen, F., Olweus, J., Horejsi, V., Skubitz, K.M., Thompson, J.S., Vilella, R., Symington, F.W. J. Immunol. (1992) [Pubmed]
  30. Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines. Escrevente, C., Machado, E., Brito, C., Reis, C.A., Stoeck, A., Runz, S., Marmé, A., Altevogt, P., Costa, J. Int. J. Oncol. (2006) [Pubmed]
  31. The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21. Reguigne, I., James, M.R., Richard, C.W., Mollicone, R., Seawright, A., Lowe, J.B., Oriol, R., Couillin, P. Cytogenet. Cell Genet. (1994) [Pubmed]
  32. Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. Stocks, S.C., Albrechtsen, M., Kerr, M.A. Biochem. J. (1990) [Pubmed]
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