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Gene Review

ST6GAL1  -  ST6 beta-galactosamide alpha-2,6...

Homo sapiens

Synonyms: Alpha 2,6-ST 1, B-cell antigen CD75, Beta-galactoside alpha-2,6-sialyltransferase 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, SIAT1, ...
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Disease relevance of ST6GAL1


Psychiatry related information on ST6GAL1


High impact information on ST6GAL1


Chemical compound and disease context of ST6GAL1


Biological context of ST6GAL1


Anatomical context of ST6GAL1


Associations of ST6GAL1 with chemical compounds

  • These results indicate that alpha 2,6-ST expression is a critical regulatory step in the formation of the Ags that are recognized by these mAb, and that an alpha 2,6-linked sialic acid residue is an essential component of each Ag [22].
  • A single gene, SIAT1, encodes ST6Gal I, the sialyltransferase that mediates transfer of alpha2,6-linked sialic acids to Galbeta1, 4GlcNAc termini of N-linked glycoproteins [19].
  • The LBSA content and sialyltransferase activity were the highest in the GD group (164 +/- 4.44 versus 120 +/- 2.00 nmoL/g, p = 0.005 and 1625 +/- 283.5 versus 324 +/- 54.2 cpm/mg of protein, p < 0.005 compared to control group C) [23].
  • Using tumor tissues fixed in formaldehyde, amplification of genomic DNA of Fuc-T and ST was performed by PCR and correlated with sLe(x) staining and patient prognosis [24].
  • On mature thymocytes, S. nigra agglutinin appeared to bind primarily to the cell-surface glycoprotein CD45; since only the mature thymocytes expressed the CD45RA isoform, while both mature and immature populations expressed the CD45R0 isoform, CD45RA may be a preferred substrate for ST6N [25].
  • Preventing ST6Gal-I down-regulation (and therefore integrin hyposialylation), through BACE1 inhibition or ST6Gal-I constitutive overexpression, eliminates VCAM-1 binding [26].

Physical interactions of ST6GAL1


Enzymatic interactions of ST6GAL1


Regulatory relationships of ST6GAL1


Other interactions of ST6GAL1

  • alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma [24].
  • Since expression of the alpha 2,6-ST protein was shown to be limited to the Golgi apparatus, the cell-surface HB-6 Ag was demonstrated to be the product of alpha 2,6-ST activity [22].
  • There was a positive correlation between the increased sialyltransferase-1 mRNA level and the TSH-receptor antibody titer determined by the TRAK test [23].
  • RNase protection analysis of different cell types showed that the transcript corresponding to the alpha 2,6-sialyltransferase cDNA isolated from a B-cell library resided only in mature B cells [31].
  • Extracts from L cells transfected with ST3Gal VI cDNA in a expression vector and a fusion protein with protein A showed an enzyme activity of alpha2, 3-sialyltransferase toward Galbeta1,4GlcNAc structure on glycoproteins and glycolipids [32].

Analytical, diagnostic and therapeutic context of ST6GAL1


  1. Chromosome mapping and organization of the human beta-galactoside alpha 2,6-sialyltransferase gene. Differential and cell-type specific usage of upstream exon sequences in B-lymphoblastoid cells. Wang, X., Vertino, A., Eddy, R.L., Byers, M.G., Jani-Sait, S.N., Shows, T.B., Lau, J.T. J. Biol. Chem. (1993) [Pubmed]
  2. Elevation of ST6Gal I activity in malignant and transitional tissue in human colorectal cancer. Vázquez-Martín, C., Gil-Martín, E., Fernández-Briera, A. Oncology (2005) [Pubmed]
  3. Expression of beta-galactoside alpha2,6 sialyltransferase and of alpha2,6-sialylated glycoconjugates in normal human liver, hepatocarcinoma, and cirrhosis. Dall'Olio, F., Chiricolo, M., D'Errico, A., Gruppioni, E., Altimari, A., Fiorentino, M., Grigioni, W.F. Glycobiology (2004) [Pubmed]
  4. Transcriptional regulation of human beta-galactoside alpha2,6-sialyltransferase (hST6Gal I) gene in colon adenocarcinoma cell line. Xu, L., Kurusu, Y., Takizawa, K., Tanaka, J., Matsumoto, K., Taniguchi, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  5. Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. Wang, P.H., Lee, W.L., Lee, Y.R., Juang, C.M., Chen, Y.J., Chao, H.T., Tsai, Y.C., Yuan, C.C. Gynecol. Oncol. (2003) [Pubmed]
  6. A decrease in serum sialyltransferase levels in Alzheimer's disease. Maguire, T.M., Gillian, A.M., O'Mahony, D., Coughlan, C.M., Dennihan, A., Breen, K.C. Neurobiol. Aging (1994) [Pubmed]
  7. Positive association between SIAT8B and schizophrenia in the Chinese Han population. Tao, R., Li, C., Zheng, Y., Qin, W., Zhang, J., Li, X., Xu, Y., Shi, Y.Y., Feng, G., He, L. Schizophr. Res. (2007) [Pubmed]
  8. Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase. Simpson, M.A., Cross, H., Proukakis, C., Priestman, D.A., Neville, D.C., Reinkensmeier, G., Wang, H., Wiznitzer, M., Gurtz, K., Verganelaki, A., Pryde, A., Patton, M.A., Dwek, R.A., Butters, T.D., Platt, F.M., Crosby, A.H. Nat. Genet. (2004) [Pubmed]
  9. The B lymphocyte surface antigen CD75 is not an alpha-2,6-sialyltransferase but is a carbohydrate antigen, the production of which requires the enzyme. Munro, S., Bast, B.J., Colley, K.J., Tedder, T.F. Cell (1992) [Pubmed]
  10. The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells. Stamenkovic, I., Sgroi, D., Aruffo, A., Sy, M.S., Anderson, T. Cell (1991) [Pubmed]
  11. Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines. Lindhout, E., Lakeman, A., Mevissen, M.L., de Groot, C. J. Exp. Med. (1994) [Pubmed]
  12. The B cell antigen CD75 is a cell surface sialytransferase. Stamenkovic, I., Asheim, H.C., Deggerdal, A., Blomhoff, H.K., Smeland, E.B., Funderud, S. J. Exp. Med. (1990) [Pubmed]
  13. Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors. Reboul, P., George, P., Geoffroy, J., Louisot, P., Broquet, P. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  14. Regulation of sialyltransferase expression by estradiol and 4-OH-tamoxifen in the human breast cancer cell MCF-7. Peyrat, J.P., Recchi, M.A., Hebbar, M., Pawlowski, V., Hornez, L., Dong-Lebouhris, X., Hondermarck, H., Harduin-Lepers, A., Delannoy, P. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
  15. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Bouchet, V., Hood, D.W., Li, J., Brisson, J.R., Randle, G.A., Martin, A., Li, Z., Goldstein, R., Schweda, E.K., Pelton, S.I., Richards, J.C., Moxon, E.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs. Ye, J.N., Gu, T.G., Xia, L.A., Murphy, M.J., Lee, W., Gao, N.H., Gu, J.R., Fuhrer, J.P. Cancer Res. (1990) [Pubmed]
  17. Effect of retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in normal and transformed cells. Moskal, J.R., Lockney, M.W., Marvel, C.C., Trosko, J.E., Sweeley, C.C. Cancer Res. (1987) [Pubmed]
  18. Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer. Gretschel, S., Haensch, W., Schlag, P.M., Kemmner, W. Oncology (2003) [Pubmed]
  19. Transcription of the beta-galactoside alpha2,6-sialyltransferase gene (SIAT1) in B-lymphocytes: cell type-specific expression correlates with presence of the divergent 5'-untranslated sequence. Lo, N.W., Lau, J.T. Glycobiology (1999) [Pubmed]
  20. Isolation and characterization of a partial cDNA for a human sialyltransferase. Lance, P., Lau, K.M., Lau, J.T. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  21. Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands. Hanasaki, K., Varki, A., Stamenkovic, I., Bevilacqua, M.P. J. Biol. Chem. (1994) [Pubmed]
  22. The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. Bast, B.J., Zhou, L.J., Freeman, G.J., Colley, K.J., Ernst, T.J., Munro, J.M., Tedder, T.F. J. Cell Biol. (1992) [Pubmed]
  23. Thyroid sialyltransferase mRNA level and activity are increased in Graves' disease. Kiljański, J., Ambroziak, M., Pachucki, J., Jazdzewski, K., Wiechno, W., Stachlewska, E., Górnicka, B., Bogdańska, M., Nauman, J., Bartoszewicz, Z. Thyroid (2005) [Pubmed]
  24. alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma. Ogawa, J.I., Inoue, H., Koide, S. Cancer (1997) [Pubmed]
  25. Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression. Baum, L.G., Derbin, K., Perillo, N.L., Wu, T., Pang, M., Uittenbogaart, C. J. Biol. Chem. (1996) [Pubmed]
  26. Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins. Woodard-Grice, A.V., McBrayer, A.C., Wakefield, J.K., Zhuo, Y., Bellis, S.L. J. Biol. Chem. (2008) [Pubmed]
  27. Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Kitazume, S., Suzuki, M., Saido, T.C., Hashimoto, Y. Glycoconj. J. (2004) [Pubmed]
  28. Glycoprotein recycling to the galactosyltransferase compartment of the Golgi complex. Huang, K.M., Snider, M.D. J. Biol. Chem. (1993) [Pubmed]
  29. Deficient cytidine monophospho-N-acetylneuraminic acid: glycoprotein sialyltransferase activity in a clone of KB cells with altered cell fusion ability. Toyama, S., Koyama, A.H., Toyama, S. J. Biol. Chem. (1983) [Pubmed]
  30. Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides. Zurita, A.R., Maccioni, H.J., Daniotti, J.L. Biochem. J. (2001) [Pubmed]
  31. Cell-specific expression of human beta-galactoside alpha 2,6-sialyltransferase transcripts differing in the 5' untranslated region. Aasheim, H.C., Aas-Eng, D.A., Deggerdal, A., Blomhoff, H.K., Funderud, S., Smeland, E.B. Eur. J. Biochem. (1993) [Pubmed]
  32. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. Okajima, T., Fukumoto, S., Miyazaki, H., Ishida, H., Kiso, M., Furukawa, K., Urano, T., Furukawa, K. J. Biol. Chem. (1999) [Pubmed]
  33. Characterization of sialyltransferase mutants using surface plasmon resonance. Laroy, W., Ameloot, P., Contreras, R. Glycobiology (2001) [Pubmed]
  34. Regulation of B cell development and B cell signalling by CD22 and its ligands {alpha}2,6-linked sialic acids. Ghosh, S., Bandulet, C., Nitschke, L. Int. Immunol. (2006) [Pubmed]
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