The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LHX1  -  LIM homeobox 1

Homo sapiens

Synonyms: Homeobox protein Lim-1, LIM homeobox protein 1, LIM-1, LIM/homeobox protein Lhx1, LIM1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LHX1


Psychiatry related information on LHX1


High impact information on LHX1


Biological context of LHX1


Other interactions of LHX1

  • Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5 [11].
  • cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4 [12].
  • Other LIM-homeobox proteins (Lim-1, -2 and -3 and Islet-2) are not expressed either in normal or Frorieps' DRG at early stages of development [13].

Analytical, diagnostic and therapeutic context of LHX1

  • Combining biolistics with immunohistochemistry we showed that transfected cells, which have also been translocated in a ventricular direction were positive for the horizontal cell markers Lim1 and Prox1 [14].


  1. Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis. Ottolenghi, C., Moreira-Filho, C., Mendonça, B.B., Barbieri, M., Fellous, M., Berkovitz, G.D., McElreavey, K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  2. Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. Green, E.K., Elvidge, G.P., Owen, M.J., Craddock, N. Psychiatr. Genet. (2003) [Pubmed]
  3. Requirement for Lim1 in head-organizer function. Shawlot, W., Behringer, R.R. Nature (1995) [Pubmed]
  4. The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. Sánchez-García, I., Osada, H., Forster, A., Rabbitts, T.H. EMBO J. (1993) [Pubmed]
  5. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Pillai, A., Mansouri, A., Behringer, R., Westphal, H., Goulding, M. Development (2007) [Pubmed]
  6. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. Velyvis, A., Yang, Y., Wu, C., Qin, J. J. Biol. Chem. (2001) [Pubmed]
  7. Neural development. A 'LIM code' for motor neurons? Lumsden, A. Curr. Biol. (1995) [Pubmed]
  8. Assignment of LHX1 to human chromosome bands 17q11.2-->q12 by use of radiation hybrid mapping and somatic cell hybridization. Phillips, J.C. Cytogenet. Genome Res. (2002) [Pubmed]
  9. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. Narlis, M., Grote, D., Gaitan, Y., Boualia, S.K., Bouchard, M. J. Am. Soc. Nephrol. (2007) [Pubmed]
  10. The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells. Girardin, S.E., Benjannet, S., Barale, J.C., Chrétien, M., Seidah, N.G. FEBS Lett. (1998) [Pubmed]
  11. Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5. Zhao, Y., Hermesz, E., Yarolin, M.C., Westphal, H. Gene (2000) [Pubmed]
  12. cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., Qiang, B. Brain Res. (2002) [Pubmed]
  13. Differences in neuronal differentiation between the transient cranial (Frorieps') and normal dorsal root ganglia. Avivi, C., Cui, S., Goren, S., Goldstein, R.S. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  14. Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development. Edqvist, P.H., Hallböök, F. Development (2004) [Pubmed]
WikiGenes - Universities