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Gene Review

LHX1  -  LIM homeobox 1

Homo sapiens

Synonyms: Homeobox protein Lim-1, LIM homeobox protein 1, LIM-1, LIM/homeobox protein Lhx1, LIM1, ...
 
 
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Disease relevance of LHX1

 

Psychiatry related information on LHX1

 

High impact information on LHX1

 

Biological context of LHX1

 

Other interactions of LHX1

  • Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5 [11].
  • cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4 [12].
  • Other LIM-homeobox proteins (Lim-1, -2 and -3 and Islet-2) are not expressed either in normal or Frorieps' DRG at early stages of development [13].
 

Analytical, diagnostic and therapeutic context of LHX1

  • Combining biolistics with immunohistochemistry we showed that transfected cells, which have also been translocated in a ventricular direction were positive for the horizontal cell markers Lim1 and Prox1 [14].

References

  1. Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis. Ottolenghi, C., Moreira-Filho, C., Mendonça, B.B., Barbieri, M., Fellous, M., Berkovitz, G.D., McElreavey, K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  2. Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. Green, E.K., Elvidge, G.P., Owen, M.J., Craddock, N. Psychiatr. Genet. (2003) [Pubmed]
  3. Requirement for Lim1 in head-organizer function. Shawlot, W., Behringer, R.R. Nature (1995) [Pubmed]
  4. The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. Sánchez-García, I., Osada, H., Forster, A., Rabbitts, T.H. EMBO J. (1993) [Pubmed]
  5. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Pillai, A., Mansouri, A., Behringer, R., Westphal, H., Goulding, M. Development (2007) [Pubmed]
  6. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. Velyvis, A., Yang, Y., Wu, C., Qin, J. J. Biol. Chem. (2001) [Pubmed]
  7. Neural development. A 'LIM code' for motor neurons? Lumsden, A. Curr. Biol. (1995) [Pubmed]
  8. Assignment of LHX1 to human chromosome bands 17q11.2-->q12 by use of radiation hybrid mapping and somatic cell hybridization. Phillips, J.C. Cytogenet. Genome Res. (2002) [Pubmed]
  9. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. Narlis, M., Grote, D., Gaitan, Y., Boualia, S.K., Bouchard, M. J. Am. Soc. Nephrol. (2007) [Pubmed]
  10. The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells. Girardin, S.E., Benjannet, S., Barale, J.C., Chrétien, M., Seidah, N.G. FEBS Lett. (1998) [Pubmed]
  11. Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5. Zhao, Y., Hermesz, E., Yarolin, M.C., Westphal, H. Gene (2000) [Pubmed]
  12. cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., Qiang, B. Brain Res. (2002) [Pubmed]
  13. Differences in neuronal differentiation between the transient cranial (Frorieps') and normal dorsal root ganglia. Avivi, C., Cui, S., Goren, S., Goldstein, R.S. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  14. Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development. Edqvist, P.H., Hallböök, F. Development (2004) [Pubmed]
 
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