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Gene Review

LHX2  -  LIM homeobox 2

Homo sapiens

Synonyms: Homeobox protein LH-2, LH-2, LH2, LIM homeobox protein 2, LIM/homeobox protein Lhx2, ...
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Disease relevance of LHX2

  • Transfection assay to the pituitary tumor derived LbetaT2 cells, and the Chinese hamster ovary cells demonstrated that CLIM2 acts as a corepressor of the porcine Lhx2 function [1].
  • Single light-harvesting complexes LH-2 from Rhodopseudomonas acidophila were immobilized on various charged surfaces under physiological conditions [2].
  • Recently, the structure of the nonameric LH-2 of Rhodopseudomonas acidophila has been determined; we report here the crystal structure of the octameric LH-2 from Rhodospirillum molischianum [3].

High impact information on LHX2

  • We found that the human protein LHX2 is able to regulate correctly ap target genes in the fly, causes the same phenotypes as Ap when ectopically produced, and most importantly rescues ap mutant phenotypes as efficiently as the fly protein [4].
  • In addition, these genes are expressed throughout the dorsal part of the spinal cord, in patterns different from those found for other genes, like LH-2 and wnt-1 [5].
  • A yeast two-hybrid screen identified the recently described melanocyte-specific gene-related gene 1 (MRG1) as an Lhx2 LIM-interacting protein [6].
  • Tissue-specific expression of the alpha-subunit gene of glycoprotein hormones involves an enhancer element designated the pituitary glycoprotein basal element, which interacts with the LIM homeodomain transcription factor, Lhx2 [6].
  • In addition, a synergistic response to Ras activation was observed when the Lhx2 LIM domain and the transactivation domain of Elk1 are directed to a minimal reporter gene [6].

Chemical compound and disease context of LHX2


Biological context of LHX2


Anatomical context of LHX2

  • In addition to finding hLH-2 expression in all cases of CML, expression was observed in lymphoid malignancies and myeloid cell lines, but not in primary cases of acute myelogenous leukaemia [10].

Associations of LHX2 with chemical compounds

  • Carotenoid stoichiometry in the LH2 crystal: no spectral evidence for the presence of the second molecule in the alpha/beta-apoprotein dimer [7].

Other interactions of LHX2


  1. Cofactor CLIM2 promotes the repressive action of LIM homeodomain transcription factor Lhx2 in the expression of porcine pituitary glycoprotein hormone alpha subunit gene. Susa, T., Sato, T., Ono, T., Kato, T., Kato, Y. Biochim. Biophys. Acta (2006) [Pubmed]
  2. Fluorescence and photobleaching dynamics of single light-harvesting complexes. Bopp, M.A., Jia, Y., Li, L., Cogdell, R.J., Hochstrasser, R.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. The crystal structure of the light-harvesting complex II (B800-850) from Rhodospirillum molischianum. Koepke, J., Hu, X., Muenke, C., Schulten, K., Michel, H. Structure (1996) [Pubmed]
  4. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Rincón-Limas, D.E., Lu, C.H., Canal, I., Calleja, M., Rodríguez-Esteban, C., Izpisúa-Belmonte, J.C., Botas, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Ben-Arie, N., McCall, A.E., Berkman, S., Eichele, G., Bellen, H.J., Zoghbi, H.Y. Hum. Mol. Genet. (1996) [Pubmed]
  6. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. Glenn, D.J., Maurer, R.A. J. Biol. Chem. (1999) [Pubmed]
  7. Carotenoid stoichiometry in the LH2 crystal: no spectral evidence for the presence of the second molecule in the alpha/beta-apoprotein dimer. Gall, A., Gardiner, A.T., Cogdell, R.J., Robert, B. FEBS Lett. (2006) [Pubmed]
  8. Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior. Rahmatpanah, F.B., Carstens, S., Guo, J., Sjahputera, O., Taylor, K.H., Duff, D., Shi, H., Davis, J.W., Hooshmand, S.I., Chitma-Matsiga, R., Caldwell, C.W. Leukemia (2006) [Pubmed]
  9. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Bendall, A.J., Rincón-Limas, D.E., Botas, J., Abate-Shen, C. Differentiation (1998) [Pubmed]
  10. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Wu, H.K., Heng, H.H., Siderovski, D.P., Dong, W.F., Okuno, Y., Shi, X.M., Tsui, L.C., Minden, M.D. Oncogene (1996) [Pubmed]
  11. Cloning and analysis of axolotl ISL2 and LHX2 LIM-homeodomain transcription factors. Showalter, A.D., Yaden, B.C., Chernoff, E.A., Rhodes, S.J. Genesis (2004) [Pubmed]
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