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Gene Review

Anp32e  -  acidic (leucine-rich) nuclear...

Mus musculus

Synonyms: 2810018A15Rik, AI047746, AI326868, Acidic leucine-rich nuclear phosphoprotein 32 family member E, CPD1, ...
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High impact information on Anp32e

  • Real-time measurement of glycogen synthesis and breakdown in perfused mouse liver showed that Cpd 1 is capable of blocking glucagon-induced glycogenolysis in a dosage-dependent manner [1].
  • Data presented provide additional evidence that ret/ptc1 is directly implicated in malignant transformation, and demonstrate the ability of Cpd 1 to interfere in the signal transduction pathway constitutively activated by the ret/ptc1 oncoprotein [2].
  • Following exposure to Cpd 1, the transformed phenotype of NIH3T3ptc1 cells was reverted, within 24 hr, to a normal fibroblast-like morphology in adherent-cell culture [2].
  • Four compounds inhibited ret/ptc1 activity in immunokinase assay (IC50 27-42 microM) including one (1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl) methylene)-2H-indol-2-one) (Cpd 1) that selectively inhibited the anchorage-independent growth of NIH3T3 transformants expressing the ret/ptc1 gene (NIH3T3ptc1 cells) [2].
  • However, when Anp32e/Cpd1 is in the cytoplasm, it co-localizes spatially with protein phosphatase 2A (PP2A) near cell membranes, far from the synapses [3].

Anatomical context of Anp32e


Associations of Anp32e with chemical compounds

  • Anp32e/Cpd1, a member of the acidic nuclear phosphoprotein (Anp)32 family, is characterized by the presence of an amino terminal domain containing four leucine-rich repeats and a carboxyl-terminal low-compositional complexity acidic region [3].


  1. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Qureshi, S.A., Rios Candelore, M., Xie, D., Yang, X., Tota, L.M., Ding, V.D., Li, Z., Bansal, A., Miller, C., Cohen, S.M., Jiang, G., Brady, E., Saperstein, R., Duffy, J.L., Tata, J.R., Chapman, K.T., Moller, D.E., Zhang, B.B. Diabetes (2004) [Pubmed]
  2. Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative. Lanzi, C., Cassinelli, G., Pensa, T., Cassinis, M., Gambetta, R.A., Borrello, M.G., Menta, E., Pierotti, M.A., Zunino, F. Int. J. Cancer (2000) [Pubmed]
  3. Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis. Costanzo, R.V., Vilá-Ortíz, G.J., Perandones, C., Carminatti, H., Matilla, A., Radrizzani, M. Eur. J. Neurosci. (2006) [Pubmed]
  4. Differential expression of CPD1 during postnatal development in the mouse cerebellum. Radrizzani, M., Vilá-Ortiz, G., Cafferata, E.G., Di Tella, M.C., González-Guerrico, A., Perandones, C., Pivetta, O.H., Carminatti, H., Idoyaga Vargas, V.P., Santa-Coloma, T.A. Brain Res. (2001) [Pubmed]
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