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Gene Review:

STNL - statin-like

Homo sapiens

This record was replaced with 1917.

Wei, H. et al., Murugkar, H.V. et al., Cicero, A.F. et al.

Cicero, Brancaleoni, Laghi, Donati, Mino,

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High impact information on STNL

In resting HUVECs, geranylgeranyl pyrophosphate (GGPP), but not farnesyl pyrophosphate (FPP) (both are isoprenoid intermediates in the cholesterol biosynthesis pathway) compromised the effect of lovastatin on PECAM-1 expression, whereas C3 toxin, an inhibitor of small G proteins, exerted statin-like effect [1].
The reduction of LDL-C reached the 20%, and it is similar to that obtained with a well-known effective statin like Pravastatin [2].

Analytical, diagnostic and therapeutic context of STNL

Paratyphi B (5) serovars were subjected to polymerase chain reaction (PCR) assay for the detection of stnl ssf and pef genes using their specific primers and the PCR products were analysed by 1 per cent agarose gel electrophoresis for the presence of the respective genes [3].

References

Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. Wei, H., Fang, L., Song, J., Chatterjee, S. FEBS Lett. (2005) [Pubmed]
Antihyperlipidaemic effect of a Monascus purpureus brand dietary supplement on a large sample of subjects at low risk for cardiovascular disease: a pilot study. Cicero, A.F., Brancaleoni, M., Laghi, L., Donati, F., Mino, M. Complementary therapies in medicine. (2005) [Pubmed]
Distribution of virulence genes in Salmonella serovars isolated from man & animals. Murugkar, H.V., Rahman, H., Dutta, P.K. Indian J. Med. Res. (2003) [Pubmed]

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