The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

GGDP     [hydroxy-[(2E,6E,10E)- 3,7,11,15...

Synonyms: GGPP, CHEBI:15831, CHEBI:48861, G6025_SIGMA, HMDB04486, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of all-trans-Geranylgeranyl pyrophosphate

  • In Escherichia coli cells that express both the Arabidopsis GA1 gene and the Erwinia uredovora gene encoding GGPP synthase, CPP was accumulated [1].
  • The two enzymes, each of which was overproduced in Escherichia coli and purified to homogeneity, converted GGDP into terpentetriene [2].
  • The two cyclase genes were also expressed in Streptomyces lividans together with the GGDP synthase gene under the control of the ermE* constitutive promoter [2].

High impact information on all-trans-Geranylgeranyl pyrophosphate


Chemical compound and disease context of all-trans-Geranylgeranyl pyrophosphate


Biological context of all-trans-Geranylgeranyl pyrophosphate


Anatomical context of all-trans-Geranylgeranyl pyrophosphate


Associations of all-trans-Geranylgeranyl pyrophosphate with other chemical compounds

  • This result indicates that the GA1 gene encodes the enzyme ent-kaurene synthetase A, which catalyzes the conversion of GGPP to CPP [1].
  • C3 exoenzyme, an inhibitor of the geranylgeranylated-activated Rho protein, reproduced the effect of lovastatin on tPA and PAI- activity and blocked its reversion by GGPP [15].
  • Introduction of the crtB gene into A. tumefaciens led to the conversion of GGPP into phytoene [6].
  • Furthermore, GGTI, a specific inhibitor of GGPP, mimicked the effect of simvastatin of tube formation and the formation of honeycombs whereas FTI, a specific inhibitor of the farnesylation of Ras, had no effect [16].

Gene context of all-trans-Geranylgeranyl pyrophosphate


  1. The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Sun, T.P., Kamiya, Y. Plant Cell (1994) [Pubmed]
  2. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. Dairi, T., Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K., Seto, H. J. Bacteriol. (2001) [Pubmed]
  3. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. Dunn, S.E., Youssef, S., Goldstein, M.J., Prod'homme, T., Weber, M.S., Zamvil, S.S., Steinman, L. J. Exp. Med. (2006) [Pubmed]
  4. A role for geranylgeranylation in interleukin-1beta secretion. Mandey, S.H., Kuijk, L.M., Frenkel, J., Waterham, H.R. Arthritis Rheum. (2006) [Pubmed]
  5. Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin. Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K., Seto, H., Dairi, T. J. Biol. Chem. (2002) [Pubmed]
  6. New functional assignment of the carotenogenic genes crtB and crtE with constructs of these genes from Erwinia species. Sandmann, G., Misawa, N. FEMS Microbiol. Lett. (1992) [Pubmed]
  7. Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors. Huber, H.E., Robinson, R.G., Watkins, A., Nahas, D.D., Abrams, M.T., Buser, C.A., Lobell, R.B., Patrick, D., Anthony, N.J., Dinsmore, C.J., Graham, S.L., Hartman, G.D., Lumma, W.C., Williams, T.M., Heimbrook, D.C. J. Biol. Chem. (2001) [Pubmed]
  8. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Xia, Z., Tan, M.M., Wong, W.W., Dimitroulakos, J., Minden, M.D., Penn, L.Z. Leukemia (2001) [Pubmed]
  9. Isoprenoids influence expression of Ras and Ras-related proteins. Holstein, S.A., Wohlford-Lenane, C.L., Hohl, R.J. Biochemistry (2002) [Pubmed]
  10. Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. Nishida, S., Tsubaki, M., Hoshino, M., Namimatsu, A., Uji, H., Yoshioka, S., Tanimori, Y., Yanae, M., Iwaki, M., Irimajiri, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. Tatsuno, I., Tanaka, T., Oeda, T., Yasuda, T., Kitagawa, M., Saito, Y., Hirai, A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  12. Statins induce differentiation and cell death in neurons and astroglia. M??rz, P., Otten, U., Miserez, A.R. Glia (2007) [Pubmed]
  13. Expression, regulation, and activity of ABCA1 in human cell lines. Denis, M., Bissonnette, R., Haidar, B., Krimbou, L., Bouvier, M., Genest, J. Mol. Genet. Metab. (2003) [Pubmed]
  14. Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells. Terano, T., Shiina, T., Noguchi, Y., Tanaka, T., Tatsuno, I., Saito, Y., Yasuda, T., Kitagawa, M., Hirai, A. J. Atheroscler. Thromb. (1998) [Pubmed]
  15. Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells: role of geranylgeranylation and Rho proteins. Essig, M., Vrtovsnik, F., Nguyen, G., Sraer, J.D., Friedlander, G. J. Am. Soc. Nephrol. (1998) [Pubmed]
  16. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Park, H.J., Zhang, Y., Georgescu, S.P., Johnson, K.L., Kong, D., Galper, J.B. Stem cell reviews (2006) [Pubmed]
  17. Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. Thomä, N.H., Iakovenko, A., Goody, R.S., Alexandrov, K. J. Biol. Chem. (2001) [Pubmed]
  18. A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK. Nishida, S., Fujii, Y., Yoshioka, S., Kikuichi, S., Tsubaki, M., Irimajiri, K. Life Sci. (2003) [Pubmed]
  19. Diterpene synthesis in Stevia rebaudiana: recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway. Richman, A.S., Gijzen, M., Starratt, A.N., Yang, Z., Brandle, J.E. Plant J. (1999) [Pubmed]
  20. Rosuvastatin reduces MMP-7 secretion by human monocyte-derived macrophages: potential relevance to atherosclerotic plaque stability. Furman, C., Copin, C., Kandoussi, M., Davidson, R., Moreau, M., McTaggiart, F., Chapman, M.J., Fruchart, J.C., Rouis, M. Atherosclerosis (2004) [Pubmed]
WikiGenes - Universities