The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AGN-PC-008RIJ     (hydroxy-(3,7,11,15- tetramethylhexadeca-2...

Synonyms: AG-K-15460, CTK5J8852, AC1L19WN
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Geranylgeranyl diphosphate

 

High impact information on Geranylgeranyl diphosphate

 

Chemical compound and disease context of Geranylgeranyl diphosphate

 

Biological context of Geranylgeranyl diphosphate

 

Anatomical context of Geranylgeranyl diphosphate

 

Associations of Geranylgeranyl diphosphate with other chemical compounds

 

Gene context of Geranylgeranyl diphosphate

 

Analytical, diagnostic and therapeutic context of Geranylgeranyl diphosphate

References

  1. Rab9 functions in transport between late endosomes and the trans Golgi network. Lombardi, D., Soldati, T., Riederer, M.A., Goda, Y., Zerial, M., Pfeffer, S.R. EMBO J. (1993) [Pubmed]
  2. Expression, purification, crystallization and preliminary X-ray studies of geranylgeranyl diphosphate synthase from Thermus thermophilus HB8. Nishio, K., Nodake, Y., Hamada, K., Suto, K., Nakagawa, N., Kuramitsu, S., Miura, K. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  3. Purification and enzymatic characterization of the geranylgeranyl pyrophosphate synthase from Erwinia uredovora after expression in Escherichia coli. Wiedemann, M., Misawa, N., Sandmann, G. Arch. Biochem. Biophys. (1993) [Pubmed]
  4. Comparative specificity of geranylgeranyl pyrophosphate synthetase of Micrococcus lysodeikticus and pumpkin. Shinka, T., Ogura, K., Seto, S. J. Biochem. (1975) [Pubmed]
  5. Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution. Kawasaki, T., Hamano, Y., Kuzuyama, T., Itoh, N., Seto, H., Dairi, T. J. Biochem. (2003) [Pubmed]
  6. Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. Martin, G., Duez, H., Blanquart, C., Berezowski, V., Poulain, P., Fruchart, J.C., Najib-Fruchart, J., Glineur, C., Staels, B. J. Clin. Invest. (2001) [Pubmed]
  7. Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Tholl, D., Kish, C.M., Orlova, I., Sherman, D., Gershenzon, J., Pichersky, E., Dudareva, N. Plant Cell (2004) [Pubmed]
  8. Cloning and characterization of the maize An1 gene. Bensen, R.J., Johal, G.S., Crane, V.C., Tossberg, J.T., Schnable, P.S., Meeley, R.B., Briggs, S.P. Plant Cell (1995) [Pubmed]
  9. Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast. Schoendorf, A., Rithner, C.D., Williams, R.M., Croteau, R.B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Fisher, J.E., Rogers, M.J., Halasy, J.M., Luckman, S.P., Hughes, D.E., Masarachia, P.J., Wesolowski, G., Russell, R.G., Rodan, G.A., Reszka, A.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening. Kuntz, M., Römer, S., Suire, C., Hugueney, P., Weil, J.H., Schantz, R., Camara, B. Plant J. (1992) [Pubmed]
  12. Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis. Schepmann, H.G., Pang, J., Matsuda, S.P. Arch. Biochem. Biophys. (2001) [Pubmed]
  13. Ultrastructural and biochemical evidence of apoptosis induced by a novel inhibitor of protein geranylgeranylation in human MIA PaCa-2 pancreatic cancer cells. Gesi, M., Pellegrini, A., Soldani, P., Lenzi, P., Paparelli, A., Danesi, R., Nardini, D., Macchia, M. Ultrastructural pathology. (1998) [Pubmed]
  14. Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase. Toyomasu, T., Kawaide, H., Ishizaki, A., Shinoda, S., Otsuka, M., Mitsuhashi, W., Sassa, T. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  15. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Endres, M., Laufs, U., Huang, Z., Nakamura, T., Huang, P., Moskowitz, M.A., Liao, J.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  16. (S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis. Chen, A., Zhang, D., Poulter, C.D. J. Biol. Chem. (1993) [Pubmed]
  17. A salvage pathway for phytol metabolism in Arabidopsis. Ischebeck, T., Zbierzak, A.M., Kanwischer, M., Dörmann, P. J. Biol. Chem. (2006) [Pubmed]
  18. Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase. Ohnuma, S., Suzuki, M., Nishino, T. J. Biol. Chem. (1994) [Pubmed]
  19. Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T., Morita, Y., Sagami, I., Sagami, H., Ogura, K. J. Biol. Chem. (1999) [Pubmed]
  20. Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis. Kawaide, H., Imai, R., Sassa, T., Kamiya, Y. J. Biol. Chem. (1997) [Pubmed]
  21. The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. Otto, J.C., Casey, P.J. J. Biol. Chem. (1996) [Pubmed]
  22. Substrate specificity of cis-prenyltransferase in rat liver microsomes. Ericsson, J., Thelin, A., Chojnacki, T., Dallner, G. J. Biol. Chem. (1992) [Pubmed]
  23. Internal translational initiation in the mRNA from the Neurospora crassa albino-3 gene. Vittorioso, P., Carattoli, A., Londei, P., Macino, G. J. Biol. Chem. (1994) [Pubmed]
  24. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. Hirai, A., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Tatsuno, I., Oeda, T., Tahara, K., Terano, T., Narumiya, S., Kohn, L.D., Saito, Y. J. Biol. Chem. (1997) [Pubmed]
  25. Regulation of product chain length by isoprenyl diphosphate synthases. Tarshis, L.C., Proteau, P.J., Kellogg, B.A., Sacchettini, J.C., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  26. Molecular cloning of a Neurospora crassa carotenoid biosynthetic gene (albino-3) regulated by blue light and the products of the white collar genes. Nelson, M.A., Morelli, G., Carattoli, A., Romano, N., Macino, G. Mol. Cell. Biol. (1989) [Pubmed]
  27. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins. Essig, M., Nguyen, G., Prié, D., Escoubet, B., Sraer, J.D., Friedlander, G. Circ. Res. (1998) [Pubmed]
  28. Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. Thomä, N.H., Iakovenko, A., Goody, R.S., Alexandrov, K. J. Biol. Chem. (2001) [Pubmed]
  29. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. Li, X., Liu, L., Tupper, J.C., Bannerman, D.D., Winn, R.K., Sebti, S.M., Hamilton, A.D., Harlan, J.M. J. Biol. Chem. (2002) [Pubmed]
  30. BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. Jiang, Y., Proteau, P., Poulter, D., Ferro-Novick, S. J. Biol. Chem. (1995) [Pubmed]
  31. Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme. Witter, D.J., Poulter, C.D. Biochemistry (1996) [Pubmed]
  32. Geranylgeranyl pyrophosphate synthase encoded by the newly isolated gene GGPS6 from Arabidopsis thaliana is localized in mitochondria. Zhu, X.F., Suzuki, K., Saito, T., Okada, K., Tanaka, K., Nakagawa, T., Matsuda, H., Kawamukai, M. Plant Mol. Biol. (1997) [Pubmed]
  33. Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. Nishida, S., Tsubaki, M., Hoshino, M., Namimatsu, A., Uji, H., Yoshioka, S., Tanimori, Y., Yanae, M., Iwaki, M., Irimajiri, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  34. Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. Kainou, T., Kawamura, K., Tanaka, K., Matsuda, H., Kawamukai, M. Biochim. Biophys. Acta (1999) [Pubmed]
  35. Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. Danesi, R., Figg, W.D., Reed, E., Myers, C.E. Mol. Pharmacol. (1995) [Pubmed]
  36. Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates. van Beek, E., Pieterman, E., Cohen, L., Löwik, C., Papapoulos, S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  37. Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. Sagami, H., Korenaga, T., Ogura, K. J. Biochem. (1993) [Pubmed]
  38. Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. Engprasert, S., Taura, F., Kawamukai, M., Shoyama, Y. BMC Plant Biol. (2004) [Pubmed]
 
WikiGenes - Universities