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SPTAN1  -  spectrin, alpha, non-erythrocytic 1

Homo sapiens

Synonyms: Alpha-II spectrin, EIEE5, Fodrin alpha chain, NEAS, SPTA2, ...
 
 
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Disease relevance of SPTAN1

 

High impact information on SPTAN1

  • Dynamic molecular modeling of the 11th structural repeat of human alpha II spectrin incorporating the various mutations suggests that the calpain cleavage site with its flanking calmodulin binding domain interrupts helix C of alpha II spectrin's 11th repetitive unit without significantly disrupting the repeat's triple-helical motif [3].
  • Activation of calpain results in the breakdown of alpha II spectrin (alpha-fodrin), a neuronal cytoskeleton protein, which has previously been detected in various in vitro and in vivo neuronal injury models [4].
  • We found a polymorphic region of an intron located in the second EF-hand of SPTAN1 gene [5].
  • Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats [6].
  • Specific degradation products of alpha II spectrin and PARP, which are known indicators of caspase activity, and apoptosis were detected on immunoblots of muscle samples taken over the postmortem period [7].
 

Biological context of SPTAN1

 

Anatomical context of SPTAN1

 

Associations of SPTAN1 with chemical compounds

  • We found that the transcriptional inhibitor, actinomycin D, induced caspase 3 activation and that caspase 3 activation is coincident with the cleavage of alpha II-spectrin protein at a primary cleavage site [2].
 

Other interactions of SPTAN1

  • Induction of the intrinsic and extrinsic pathways in HSG cells resulted in substrate cleavage by effector caspases, in particular the cleavage of alpha II spectrin, an autoantigen in Sj??gren's syndrome [8].
 

Analytical, diagnostic and therapeutic context of SPTAN1

References

  1. Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Lee, S., Baek, M., Yang, H., Bang, Y.J., Kim, W.H., Ha, J.H., Kim, D.K., Jeoung, D.I. Cancer Lett. (2002) [Pubmed]
  2. Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. Williams, S.T., Smith, A.N., Cianci, C.D., Morrow, J.S., Brown, T.L. Apoptosis (2003) [Pubmed]
  3. Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. Stabach, P.R., Cianci, C.D., Glantz, S.B., Zhang, Z., Morrow, J.S. Biochemistry (1997) [Pubmed]
  4. Selective release of calpain produced alphalI-spectrin (alpha-fodrin) breakdown products by acute neuronal cell death. Dutta, S., Chiu, Y.C., Probert, A.W., Wang, K.K. Biol. Chem. (2002) [Pubmed]
  5. Association study of a polymorphism of nonerythroid alpha-spectrin gene with schizophrenia. Murakami, N., Kitamura, N., Kajimoto, Y., Hashimoto, T., Yasuda, M., Maeda, K., Sakai, N., Shirakawa, O., Nishino, N., Tanaka, C., Saito, N. Am. J. Med. Genet. (1999) [Pubmed]
  6. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Aikman, J., O'Steen, B., Silver, X., Torres, R., Boslaugh, S., Blackband, S., Padgett, K., Wang, K.K., Hayes, R., Pineda, J. Dev. Neurosci. (2006) [Pubmed]
  7. Changes in caspase activity during the postmortem conditioning period and its relationship to shear force in porcine longissimus muscle. Kemp, C.M., Bardsley, R.G., Parr, T. J. Anim. Sci. (2006) [Pubmed]
  8. Interferon-gamma sensitizes the human salivary gland cell line, HSG, to tumor necrosis factor-alpha induced activation of dual apoptotic pathways. Kulkarni, K., Selesniemi, K., Brown, T.L. Apoptosis (2006) [Pubmed]
  9. Localization of the human alpha-fodrin gene (SPTAN1) to 9q33-->q34 by fluorescence in situ hybridization. Upender, M., Gallagher, P.G., Moon, R.T., Ward, D.C., Forget, B.G. Cytogenet. Cell Genet. (1994) [Pubmed]
 
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