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Gene Review

SSX5  -  synovial sarcoma, X breakpoint 5

Homo sapiens

Synonyms: Protein SSX5
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Disease relevance of SSX5

  • Recently, however, it was found that these two genes, as well as the highly homologous SSX4 and SSX5 genes, are aberrantly expressed in different types of cancers, including melanomas [1].
  • In 15 patients with cirrhosis and 15 other non-tumor patients, none of the SSX-2 and SSX-5 mRNA was detected in liver tissue or peripheral blood [2].

High impact information on SSX5

  • The SSX gene family is composed of at least five functional and highly homologous members, SSX1 to SSX5, that are normally expressed in only the testis and thyroid [3].
  • SSX-1, -2, and -4 were found to be expressed in 8%, 15% and 15%, of the tumors, respectively, while the expression of the SSX-5 gene was rare (7/325), and SSX-3 expression was not detected [4].


  1. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos, N.R., Torensma, R., de Vries, T.J., Schreurs, M.W., de Bruijn, D.R., Kater-Baats, E., Ruiter, D.J., Adema, G.J., van Muijen, G.N., van Kessel, A.G. Cancer Res. (2000) [Pubmed]
  2. Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma. Wu, L.Q., Lu, Y., Wang, X.F., Lv, Z.H., Zhang, B., Yang, J.Y. Life Sci. (2006) [Pubmed]
  3. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. de Bruijn, D.R., dos Santos, N.R., Kater-Baats, E., Thijssen, J., van den Berk, L., Stap, J., Balemans, M., Schepens, M., Merkx, G., van Kessel, A.G. Genes Chromosomes Cancer (2002) [Pubmed]
  4. Expression of SSX genes in human tumors. Türeci, O., Chen, Y.T., Sahin, U., Güre, A.O., Zwick, C., Villena, C., Tsang, S., Seitz, G., Old, L.J., Pfreundschuh, M. Int. J. Cancer (1998) [Pubmed]
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