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Gene Review

SSX3  -  synovial sarcoma, X breakpoint 3

Homo sapiens

Synonyms: CT5.3, Cancer/testis antigen 5.3, Protein SSX3
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Disease relevance of SSX3

  • Analysis of t(X;18) translocation in synovial sarcoma had previously led to the definition of the SSX2 gene, the fusion partner on chromosome X. Subsequent screening of testicular cDNA libraries identified 2 highly homologous genes, SSX1 and SSX3 [1].
  • To define additional CT antigens, we have immuno-screened a testicular cDNA expression library with an allogeneic serum from a melanoma patient, and both SSX2 and SSX3 were isolated [1].

High impact information on SSX3

  • In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues [2].
  • SSX-1, -2, and -4 were found to be expressed in 8%, 15% and 15%, of the tumors, respectively, while the expression of the SSX-5 gene was rare (7/325), and SSX-3 expression was not detected [3].
  • However, we conclude from our RT-PCR data and from results reported in the literature that SSX3 does not act as a fusion partner to SYT in any of the 44 independent synovial sarcomas thus far tested [4].

Biological context of SSX3


  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. Gure, A.O., Türeci, O., Sahin, U., Tsang, S., Scanlan, M.J., Jäger, E., Knuth, A., Pfreundschuh, M., Old, L.J., Chen, Y.T. Int. J. Cancer (1997) [Pubmed]
  2. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos, N.R., Torensma, R., de Vries, T.J., Schreurs, M.W., de Bruijn, D.R., Kater-Baats, E., Ruiter, D.J., Adema, G.J., van Muijen, G.N., van Kessel, A.G. Cancer Res. (2000) [Pubmed]
  3. Expression of SSX genes in human tumors. Türeci, O., Chen, Y.T., Sahin, U., Güre, A.O., Zwick, C., Villena, C., Tsang, S., Seitz, G., Old, L.J., Pfreundschuh, M. Int. J. Cancer (1998) [Pubmed]
  4. A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. de Leeuw, B., Balemans, M., Geurts van Kessel, A. Cytogenet. Cell Genet. (1996) [Pubmed]
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