The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SSX4  -  synovial sarcoma, X breakpoint 4

Homo sapiens

Synonyms: CT5.4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SSX4


High impact information on SSX4


Biological context of SSX4


Anatomical context of SSX4

  • In this study, we have analyzed CD4+ T cell responses directed against the Ag encoded by SSX-4 [8].
  • All normal tissues (n=6), with the exception of testis, normal bone marrow (BM, n=12) and normal peripheral blood (PBL, n=10) were negative for SSX-2 and SSX-4 expression [11].

Regulatory relationships of SSX4

  • Seventy-two percent (13/18) of stage 4 NB expressed SSX-2 and 67% (12/18) expressed SSX-4 [11].

Other interactions of SSX4


Analytical, diagnostic and therapeutic context of SSX4

  • Antibodies to SSX-2 and SSX-4 were detectable by ELISA and RAYS in two patients [10].
  • In this study, sixty-seven neuroblastomas (NB) (12 stage 1, 13 stage 2, 12 stage 3, 12 stage 4S and 13 stage 4) were examined by RT-PCR and a sensitive chemiluminescent detection method for SSX-2 and SSX-4 expression [11].


  1. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos, N.R., Torensma, R., de Vries, T.J., Schreurs, M.W., de Bruijn, D.R., Kater-Baats, E., Ruiter, D.J., Adema, G.J., van Muijen, G.N., van Kessel, A.G. Cancer Res. (2000) [Pubmed]
  2. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. Brodin, B., Haslam, K., Yang, K., Bartolazzi, A., Xie, Y., Starborg, M., Lundeberg, J., Larsson, O. Gene (2001) [Pubmed]
  3. SSX expression in gynecological cancers and antibody response in patients. Hasegawa, K., Koizumi, F., Noguchi, Y., Hongo, A., Mizutani, Y., Kodama, J., Hiramatsu, Y., Nakayama, E. Cancer Immun. (2004) [Pubmed]
  4. Expression of cancer testis genes in human brain tumors. Sahin, U., Koslowski, M., Türeci, O., Eberle, T., Zwick, C., Romeike, B., Moringlane, J.R., Schwechheimer, K., Feiden, W., Pfreundschuh, M. Clin. Cancer Res. (2000) [Pubmed]
  5. Expression of cancer/testis (CT) antigens in lung cancer. Tajima, K., Obata, Y., Tamaki, H., Yoshida, M., Chen, Y.T., Scanlan, M.J., Old, L.J., Kuwano, H., Takahashi, T., Takahashi, T., Mitsudomi, T. Lung Cancer (2003) [Pubmed]
  6. Re: A novel fusion gene, SYT-SSX4, in synovial sarcoma. Agus, V., Tamborini, E., Mezzelani, A., Pierotti, M.A., Pilotti, S. J. Natl. Cancer Inst. (2001) [Pubmed]
  7. A novel fusion gene, SYT-SSX4, in synovial sarcoma. Skytting, B., Nilsson, G., Brodin, B., Xie, Y., Lundeberg, J., Uhlén, M., Larsson, O. J. Natl. Cancer Inst. (1999) [Pubmed]
  8. CD4+ T cell responses to SSX-4 in melanoma patients. Ayyoub, M., Merlo, A., Hesdorffer, C.S., Rimoldi, D., Speiser, D., Cerottini, J.C., Chen, Y.T., Old, L.J., Stevanovic, S., Valmori, D. J. Immunol. (2005) [Pubmed]
  9. SSX: a multigene family with several members transcribed in normal testis and human cancer. Gure, A.O., Türeci, O., Sahin, U., Tsang, S., Scanlan, M.J., Jäger, E., Knuth, A., Pfreundschuh, M., Old, L.J., Chen, Y.T. Int. J. Cancer (1997) [Pubmed]
  10. Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells. Valmori, D., Qian, F., Ayyoub, M., Renner, C., Merlo, A., Gnjatic, S., Gjnatic, S., Stockert, E., Driscoll, D., Lele, S., Old, L.J., Odunsi, K. Clin. Cancer Res. (2006) [Pubmed]
  11. Expression of SSX-2 and SSX-4 genes in neuroblastoma. Chi, S.N., Cheung, N.K., Cheung, I.Y. Int. J. Biol. Markers (2002) [Pubmed]
  12. SSX antigens as tumor vaccine targets in human sarcoma. Ayyoub, M., Brehm, M., Metthez, G., Talbot, S., Dutoit, V., Taub, R.N., Keohan, M.L., Gure, A.O., Chen, Y.T., Williamson, B., Jungbluth, A.A., Old, L.J., Hesdorffer, C.S., Valmori, D. Cancer Immun. (2003) [Pubmed]
WikiGenes - Universities