Gene Review:
SSX1 - synovial sarcoma, X breakpoint 1
Homo sapiens
Synonyms:
CT5.1, Cancer/testis antigen 5.1, Protein SSX1, SSRC, Synovial sarcoma, X breakpoint 1
- Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. Crew, A.J., Clark, J., Fisher, C., Gill, S., Grimer, R., Chand, A., Shipley, J., Gusterson, B.A., Cooper, C.S. EMBO J. (1995)
- SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs. Taylor, B.J., Reiman, T., Pittman, J.A., Keats, J.J., de Bruijn, D.R., Mant, M.J., Belch, A.R., Pilarski, L.M. J. Immunother. (2005)
- A new human synovial sarcoma cell line, HS-SY-3, with a truncated form of hybrid SYT/SSX1 gene. Sonobe, H., Takeuchi, T., Liag, S.B., Taguchi, T., Yuri, K., Shimizu, K., Iwata, J., Furihata, M., Ohtsuki, Y., Testa, J.R. Int. J. Cancer (1999)
- Detection of SYT-SSX1/2 fusion transcripts by reverse transcriptase-polymerase chain reaction (RT-PCR) is a valuable diagnostic tool in synovial sarcoma. Willeke, F., Mechtersheimer, G., Schwarzbach, M., Weitz, J., Zimmer, D., Lehnert, T., Herfarth, C., von Knebel Doeberitz, M., Ridder, R. Eur. J. Cancer (1998)
- Expression of SSX genes in the neoplastic cells of Hodgkin's lymphoma. Colleoni, G.W., Capodieci, P., Tickoo, S., Cossman, J., Filippa, D.A., Ladanyi, M. Hum. Pathol. (2002)
- SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Saito, T., Nagai, M., Ladanyi, M. Cancer Res. (2006)
- Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. Shipley, J., Crew, J., Birdsall, S., Gill, S., Clark, J., Fisher, C., Kelsey, A., Nojima, T., Sonobe, H., Cooper, C., Gusterson, B. Am. J. Pathol. (1996)
- IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Sun, Y., Gao, D., Liu, Y., Huang, J., Lessnick, S., Tanaka, S. Oncogene (2006)
- Synovial sarcomas of three children in the first decade: clinicopathological and molecular findings. Okamoto, S., Ishida, T., Ohnishi, H., MacHinami, R., Hashimoto, H. Pathol. Int. (2000)
- A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. Storlazzi, C.T., Mertens, F., Mandahl, N., Gisselsson, D., Isaksson, M., Gustafson, P., Domanski, H.A., Panagopoulos, I. Genes Chromosomes Cancer (2003)
- Molecular mechanisms underlying human synovial sarcoma development. dos Santos, N.R., de Bruijn, D.R., van Kessel, A.G. Genes Chromosomes Cancer (2001)
- SSX: a multigene family with several members transcribed in normal testis and human cancer. Gure, A.O., Türeci, O., Sahin, U., Tsang, S., Scanlan, M.J., Jäger, E., Knuth, A., Pfreundschuh, M., Old, L.J., Chen, Y.T. Int. J. Cancer (1997)
- A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas. Lim, F.L., Soulez, M., Koczan, D., Thiesen, H.J., Knight, J.C. Oncogene (1998)
- The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery. Xie, Y., Skytting, B., Nilsson, G., Grimer, R.J., Mangham, C.D., Fisher, C., Shipley, J., Bjerkehagen, B., Myklebost, O., Larsson, O. Oncogene (2002)
- The SSX gene family: characterization of 9 complete genes. Güre, A.O., Wei, I.J., Old, L.J., Chen, Y.T. Int. J. Cancer (2002)
- A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. de Leeuw, B., Balemans, M., Geurts van Kessel, A. Cytogenet. Cell Genet. (1996)
- Absence of SYT-SSX fusion products in soft tissue tumors other than synovial sarcoma. van de Rijn, M., Barr, F.G., Collins, M.H., Xiong, Q.B., Fisher, C. Am. J. Clin. Pathol. (1999)
- Long-range organization of reiterated sequences, including the SSX1 cDNA at the OATL1 cluster in Xp11.23. Chand, A., Clark, J., Cooper, C.S., Craig, I.W. Genomics (1995)
- Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells. Valmori, D., Qian, F., Ayyoub, M., Renner, C., Merlo, A., Gnjatic, S., Gjnatic, S., Stockert, E., Driscoll, D., Lele, S., Old, L.J., Odunsi, K. Clin. Cancer Res. (2006)
- Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma. Inagaki, H., Nagasaka, T., Otsuka, T., Sugiura, E., Nakashima, N., Eimoto, T. Mod. Pathol. (2000)
- Late solitary bone metastasis of a primary pulmonary synovial sarcoma with SYT-SSX1 translocation type: case report with a long follow-up. Bode-Lesniewska, B., Hodler, J., von Hochstetter, A., Guillou, L., Exner, U., Caduff, R. Virchows Arch. (2005)
- Dual colour fluorescence in situ hybridization to paraffin-embedded samples to deduce the presence of the der(X)t(X;18)(p11.2;q11.2) and involvement of either the SSX1 or SSX2 gene: a diagnostic and prognostic aid for synovial sarcoma. Lu, Y.J., Birdsall, S., Summersgill, B., Smedley, D., Osin, P., Fisher, C., Shipley, J. J. Pathol. (1999)
- Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Thomas, D.G., Giordano, T.J., Sanders, D., Biermann, S., Sondak, V.K., Trent, J.C., Yu, D., Pollock, R.E., Baker, L. Cancer (2005)
- Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue. Tvrdík, D., Povýsil, C., Svatosová, J., Dundr, P. Med. Sci. Monit. (2005)
- A poorly differentiated synovial sarcoma (SYT/SSX1) expresses neuroectodermal markers: a xenografts and in vitro culture study. Rosa, N., Samuel, N., Lopez-Guerrero, n.u.l.l., Antonio, J., Carmen, C., Antonio, P., Antonio, L.B. Diagn. Mol. Pathol. (2004)