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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Endoplasmic Reticulum, Rough

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Disease relevance of Endoplasmic Reticulum, Rough


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Chemical compound and disease context of Endoplasmic Reticulum, Rough


Biological context of Endoplasmic Reticulum, Rough


Anatomical context of Endoplasmic Reticulum, Rough


Associations of Endoplasmic Reticulum, Rough with chemical compounds


Gene context of Endoplasmic Reticulum, Rough

  • Furthermore, the endoglycosidase H-sensitive EPO-R is more stable than in the absence of gp55, a result suggesting that interaction of gp55 with the EPO-R causes it to remain within the rough endoplasmic reticulum [28].
  • Although such mutations induce enlarged rough endoplasmic reticulum (rER) as a morphological change, the metabolic trafficking of mutated COMP remains unclear [29].
  • These results indicate that the system responsible for the degradation of the probe in the rough endoplasmic reticulum and the intramembrane cleavage by gamma-secretase that produces soluble, secreted Abeta are distinct and opposing processes [30].
  • The heavy chains of the HLA-A and -B antigens were inserted asymmetrically into the rough endoplasmic reticulum of BRI 8 cells as transmembrane polypeptides [31].
  • This cleavage step is regulated by a putative sterol-sensing molecule, SREBP-activating protein (SCAP), that forms a complex with SREBPs and traffics between the rough endoplasmic reticulum and Golgi [32].

Analytical, diagnostic and therapeutic context of Endoplasmic Reticulum, Rough


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  3. Transport of protein between cytoplasmic membranes of fused cells: correspondence to processes reconstituted in a cell-free system. Rothman, J.E., Urbani, L.J., Brands, R. J. Cell Biol. (1984) [Pubmed]
  4. Mutations blocking the transport of the influenza virus hemagglutinin between the rough endoplasmic reticulum and the Golgi apparatus. Schuy, W., Will, C., Kuroda, K., Scholtissek, C., Garten, W., Klenk, H.D. EMBO J. (1986) [Pubmed]
  5. Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus. Hirschberg, C.B., Snider, M.D. Annu. Rev. Biochem. (1987) [Pubmed]
  6. Three-dimensional visualization of the rotavirus hemagglutinin structure. Shaw, A.L., Rothnagel, R., Chen, D., Ramig, R.F., Chiu, W., Prasad, B.V. Cell (1993) [Pubmed]
  7. Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein. Kelleher, D.J., Kreibich, G., Gilmore, R. Cell (1992) [Pubmed]
  8. Biosynthesis of the IgA antibody receptor: a model for the transepithelial sorting of a membrane glycoprotein. Solari, R., Kraehenbuhl, J.P. Cell (1984) [Pubmed]
  9. Characterization of the rough endoplasmic reticulum ribosome-binding activity. Nunnari, J.M., Zimmerman, D.L., Ogg, S.C., Walter, P. Nature (1991) [Pubmed]
  10. Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. Lange, Y. J. Biol. Chem. (1994) [Pubmed]
  11. Immunoelectronmicroscopic study of alpha-fetoprotein synthesis in hepatoma cells. Shikata, T. Ann. N. Y. Acad. Sci. (1975) [Pubmed]
  12. Brief perinatal hypoxia impairs postnatal development of the bronchiolar epithelium. Massaro, G.D., Olivier, J., Massaro, D. Am. J. Physiol. (1989) [Pubmed]
  13. Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Li, J.P., D'Andrea, A.D., Lodish, H.F., Baltimore, D. Nature (1990) [Pubmed]
  14. Biosynthesis of gastrin. Localization of the precursor and peptide products using electron microscopic-immunogold methods. Rahier, J., Pauwels, S., Dockray, G.J. Gastroenterology (1987) [Pubmed]
  15. Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum. Muallem, S., Schoeffield, M., Pandol, S., Sachs, G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  16. Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment. Layet, C., Germain, R.N. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  17. Quantitative microscopic evaluation of the endoplasmic reticulum in developing human liver. de la Iglesia, F.A., Sturgess, J.M., McGuire, E.J., Feuer, G. Am. J. Pathol. (1976) [Pubmed]
  18. Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates. Lodish, H.F., Kong, N., Snider, M., Strous, G.J. Nature (1983) [Pubmed]
  19. Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition. Polydefkis, M., Koenig, S., Flexner, C., Obah, E., Gebo, K., Chakrabarti, S., Earl, P.L., Moss, B., Siliciano, R.F. J. Exp. Med. (1990) [Pubmed]
  20. Correlation of ultrastructural aberrations with dysplasia and flow cytometric abnormalities in Barrett's epithelium. Levine, D.S., Reid, B.J., Haggitt, R.C., Rubin, C.E., Rabinovitch, P.S. Gastroenterology (1989) [Pubmed]
  21. Effects of colchicine on the intestinal transport of endogenous lipid. Ultrastructural, biochemical, and radiochemical studies in fasting rats. Pavelka, M., Gangl, A. Gastroenterology (1983) [Pubmed]
  22. Ultrastructural localization of the progesterone receptor by an immunogold method: effect of hormone administration. Perrot-Applanat, M., Groyer-Picard, M.T., Logeat, F., Milgrom, E. J. Cell Biol. (1986) [Pubmed]
  23. Post-translational insertion of a fragment of the glucose transporter into microsomes requires phosphoanhydride bond cleavage. Mueckler, M., Lodish, H.F. Nature (1986) [Pubmed]
  24. Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum. Uitto, J., Hoffman, H., Prockop, D.J. Science (1975) [Pubmed]
  25. Processing of the asparagine-linked oligosaccharides of secreted and intracellular forms of the vesicular stomatitis virus G protein: in vivo evidence of Golgi apparatus compartmentalization. Gabel, C.A., Bergmann, J.E. J. Cell Biol. (1985) [Pubmed]
  26. Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers. Wagner, D.D., Mayadas, T., Urban-Pickering, M., Lewis, B.H., Marder, V.J. J. Cell Biol. (1985) [Pubmed]
  27. Transport and topology of galactosyltransferase in endomembranes of HeLa cells. Strous, G.J., Van Kerkhof, P., Willemsen, R., Geuze, H.J., Berger, E.G. J. Cell Biol. (1983) [Pubmed]
  28. Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Yoshimura, A., D'Andrea, A.D., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. Hashimoto, Y., Tomiyama, T., Yamano, Y., Mori, H. Am. J. Pathol. (2003) [Pubmed]
  30. gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein. Bunnell, W.L., Pham, H.V., Glabe, C.G. J. Biol. Chem. (1998) [Pubmed]
  31. Biosynthesis of HLA-A and HLA-B antigens in vivo. Owen, M.J., Kissonerghis, A.M., Lodish, H.F. J. Biol. Chem. (1980) [Pubmed]
  32. Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism. Shimano, H. Vitam. Horm. (2002) [Pubmed]
  33. Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein. Florkiewicz, R.Z., Smith, A., Bergmann, J.E., Rose, J.K. J. Cell Biol. (1983) [Pubmed]
  34. The carboxyl-terminal region of protein C is essential for its secretion. Katsumi, A., Kojima, T., Senda, T., Yamazaki, T., Tsukamoto, H., Sugiura, I., Kobayashi, S., Miyata, T., Umeyama, H., Saito, H. Blood (1998) [Pubmed]
  35. Biosynthesis and intracellular transport of the mouse macrophage Fc receptor. Green, S.A., Plutner, H., Mellman, I. J. Biol. Chem. (1985) [Pubmed]
  36. Subcellular fractionation studies on the post-translational processing of pro-adrenocorticotropic hormone/endorphin in rat intermediate pituitary. Glembotski, C.C. J. Biol. Chem. (1981) [Pubmed]
  37. Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus. Asker, N., Axelsson, M.A., Olofsson, S.O., Hansson, G.C. J. Biol. Chem. (1998) [Pubmed]
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