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Gene Review

SURF2  -  surfeit 2

Homo sapiens

Synonyms: Surf-2, Surfeit locus protein 2
 
 
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High impact information on SURF2

  • Another has sequence homology to the RPG alpha binding site associated with some ribosomal protein gene promoters and is required for efficient expression of the major but not intermediate start sites of Surf-1 and all start sites of Surf-2 [1].
  • By using in vitro DNase I, dimethyl sulfate methylation, and gel retardation assays, we have identified five putative promoter control elements between and around the Surf-1 and Surf-2 start sites [1].
  • The human Surf-1 and Surf-2 housekeeping genes are divergently transcribed and share a bi-directional, TATA-less promoter [2].
  • Although YY1 and Sp1 have previously been shown to interact both in vitro and in vivo, these proteins function independently at the Surf-1/Surf-2 promoter [2].
  • The divergently transcribed Surf-1 and Surf-2 housekeeping genes are separated by a bi-directional, TATA-less promoter which lies within a CpG-rich island [3].
 

Biological context of SURF2

 

Other interactions of SURF2

References

 
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