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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Lnp  -  limb and neural patterns

Mus musculus

Synonyms: 2310011O18Rik, 4921514L11Rik, 9530051D01Rik, AI666268, Kiaa1715, ...
 
 
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High impact information on Lnp

  • We used a targeted enhancer-trap approach to identify a DNA segment capable of directing reporter gene expression in both digits and CNS, following Lnp, Evx2, and Hoxd-specific patterns [1].
  • Studies have demonstrated that a "distal limb enhancer," remotely located upstream of the HoxD complex, is required to drive embryonic autopod expression of the posterior Hox genes as well as the two additional non-Hox genes in the region: Evx2 and Lnp [2].
  • The mouse mutation ulnaless on chromosome 2 [3].
  • The dominant skeletal mutation ulnaless (Ul) in the mouse causes extreme reduction of the radius and ulna and deformities of the tibia and fibula [3].

References

  1. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Spitz, F., Gonzalez, F., Duboule, D. Cell (2003) [Pubmed]
  2. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky, J.A., Williams, M.E., Innis, J.W. Evol. Dev. (2004) [Pubmed]
  3. The mouse mutation ulnaless on chromosome 2. Davisson, M.T., Cattanach, B.M. J. Hered. (1990) [Pubmed]
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