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Gene Review

Lnp  -  limb and neural patterns

Mus musculus

Synonyms: 2310011O18Rik, 4921514L11Rik, 9530051D01Rik, AI666268, Kiaa1715, ...
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High impact information on Lnp

  • We used a targeted enhancer-trap approach to identify a DNA segment capable of directing reporter gene expression in both digits and CNS, following Lnp, Evx2, and Hoxd-specific patterns [1].
  • Studies have demonstrated that a "distal limb enhancer," remotely located upstream of the HoxD complex, is required to drive embryonic autopod expression of the posterior Hox genes as well as the two additional non-Hox genes in the region: Evx2 and Lnp [2].
  • The mouse mutation ulnaless on chromosome 2 [3].
  • The dominant skeletal mutation ulnaless (Ul) in the mouse causes extreme reduction of the radius and ulna and deformities of the tibia and fibula [3].


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