The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KIAA1715  -  KIAA1715

Homo sapiens

Synonyms: LNP, LNP1, Protein lunapark, Ul, ulnaless
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of KIAA1715

  • LNP 509, which binds to I1Rs (Ki = 5.10(-7) M) but roughly not to alpha 2-adrenoceptors (A2Rs) (Ki > 10(-5) M), causes hypotension when injected alone into the brainstem [1].
  • Haemophilus caused LNP in 12% of patients [2].
  • Twenty-one percent of patients with CAP acquired an LNP (p < 0.025), in which Pseudomonas was the most common organism [2].

High impact information on KIAA1715

  • 5 Upon exposure to u.v. light, LNP 906 irreversibly blocked the binding of [125I]-paraiodoclonidine (PIC) to I1R, time- and dose-dependently, on PC12 cell membranes and interacted with I1R in a reversible and competitive manner in the absence of light [3].
  • 6 Finally, LNP 906 clearly antagonized the decrease in forskolin-stimulated cAMP level induced by rilmenidine, but not by melatonin [3].
  • Prior to fusion of the midfacial processes, bmp4 is expressed in the ectoderm of the LNP, MNP, and MxP in a distinct spatial and temporal manner near and at the site of fusion of the midface [4].
  • Among patients with CAD 11 showed a myocardial release of lactate during pacing (lactate producers, LP) while myocardial lactate extraction was unchanged in the remaining eight patients (lactate non-producers, LNP) [5].
  • In patients with CAD, (A-Cs) plasma citrate differences became increasingly negative during recovery from pacing, values at rest and at 3-5 min of recovery were: -5 +/- 2 mumol/l (mean +/- SD) vs. -12 +/- 5 mumol/l in LP (P less than 0.001) and -6 +/- 3 mumol/l vs. -8 +/- 4 mumol/l in LNP (P less than 0.01) [5].

Biological context of KIAA1715

  • It was shown that, when calculated by square centimeter of the decompression area, the effect of UBNP on central venous pressure (CVP) and pulmonary artery pressure (PAP) was 3-4 times greater than that of LBNP or LNP [6].

Associations of KIAA1715 with chemical compounds

  • Compounds, such as LNP 509, S 23515, S 23757 or benazoline with very high selectivities for IRs over alpha 2-adrenoceptors (A2Rs), became available recently [7].


  1. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Bousquet, P., Bruban, V., Schann, S., Greney, H., Ehrhardt, J.D., Dontenwill, M., Feldman, J. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  2. A time-dependent analysis of intensive care unit pneumonia in trauma patients. Bochicchio, G.V., Joshi, M., Bochicchio, K., Tracy, K., Scalea, T.M. The Journal of trauma. (2004) [Pubmed]
  3. LNP 906, the first high-affinity photoaffinity ligand selective for I1 imidazoline receptors. Urosevic, D., Dragan, U., Schann, S., Stephan, S., Ehrhardt, J.D., Jean-Daniel, E., Bousquet, P., Pascal, B., Greney, H., Hugues, G. Br. J. Pharmacol. (2004) [Pubmed]
  4. Bmp4 gene is expressed at the putative site of fusion in the midfacial region. Gong, S.G., Guo, C. Differentiation (2003) [Pubmed]
  5. Myocardial release of citrate and lactate during atrial pacing-induced angina pectoris. Bagger, J.P., Toftegaard Nielsen, T., Henningsen, P., Thomsen, P.E., Eyjolfsson, K. Scand. J. Clin. Lab. Invest. (1981) [Pubmed]
  6. Central circulation of a normal man during 7-day head-down tilt and decompression of various body parts. Katkov, V.E., Chestukhin, V.V., Nikolayenko, E.M., Rumyantsev, V.V., Gvozdev, S.V. Aviation, space, and environmental medicine. (1983) [Pubmed]
  7. Imidazoline receptors: a challenge. Bousquet, P., Bruban, V., Schann, S., Feldman, J. Pharmaceutica acta Helvetiae. (2000) [Pubmed]
WikiGenes - Universities