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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Fibula


High impact information on Fibula

  • Accordingly we classify the limb skeletal elements as Shh dependent or independent, with the ulna/fibula and digits other than digit 1 in the leg being Shh dependent [6].
  • Hoxd-13 misexpression in the hindlimb results in a shortening of the long bones, including the femur, the tibia, the fibula and the tarsometatarsals [7].
  • Absent fibula and craniosynostosis: a 25 year follow up [8].
  • A transverse cross-section of a 12-14 year old beagle fibula was studied with 80.7 keV radiation, and the transmission geometry was used to quantify internal strains and corresponding stresses in the mineral phase, carbonated hydroxyapatite [9].
  • Loss of fibula in mice overexpressing Hoxc11 [10].

Chemical compound and disease context of Fibula


Biological context of Fibula

  • Combined with the lack of an overt phenotype in the majority of Hoxc11 overexpressing embryos at day 13.5, the data suggest inhibition of chondrocyte differentiation during the elongation phase of the fibula bone as a primary effect of elevated Hoxc11 expression [10].
  • When applied directly into a freshly created fracture in the rabbit fibula, a single injection of the basic fibroblast growth factor and hyaluronan results in the stimulation of callus formation, increased bone formation, and earlier restoration of mechanical strength at the fracture site [13].
  • The reconstructions with the fibula flaps were successful and the 18 ITI implants that have been inserted showed good osseointegration without loss of attachment in all 4 patients after a mean observation period of 12 months [14].
  • AIM: Determination of the range of regional blood flow and fluoride influx during normal incorporation of revascularized fibula grafts used for mandibular reconstruction [15].

Anatomical context of Fibula


Associations of Fibula with chemical compounds

  • In the coronal plane, specimens were positioned in neutral, inversion, or eversion, and the contact characteristics were determined in varying positions, with and without loading the fibula, under axial loads of 350 N, 700 N, 1,050 N, and 1,400 N [20].
  • The soleus and flexor hallucis longus muscles of the fibula were dissected, and the proximal part of the pedicle was reached [21].
  • Rigidity of fibula in ethanol-fed rats and their pair-fed controls (groups A and B) were respectively 48 and 47% lower than in group C. Flexural modulus of the repair tissue in ethanol-fed rats had a 55% (P = 0.046) deficiency compared with their pair-fed controls [22].
  • Medial corpectomy, C5 to C7, and removal of OPLL, with subsequent fusion C4 to T1 using a free fibula graft resulted in clinical improvement [23].
  • However, because of the limited diameter of the fibula compared with the height of the mandible, the vertical distance between the reconstructed segment and the occlusal plane can be substantially large [24].

Gene context of Fibula


Analytical, diagnostic and therapeutic context of Fibula


  1. Stress fractures of the distal fibula presenting as monarticular flares in patients with rheumatoid arthritis. Wei, N. Arthritis Rheum. (1994) [Pubmed]
  2. Vocal cord paralysis and cystic kidney disease in Hajdu-Cheney syndrome. Fryns, J.P., Stinckens, C., Feenstra, L. Clin. Genet. (1997) [Pubmed]
  3. Cytokeratin expression and distribution in adamantinoma of the long bones and osteofibrous dysplasia of tibia and fibula. An immunohistochemical study correlated to histogenesis. Benassi, M.S., Campanacci, L., Gamberi, G., Ferrari, C., Picci, P., Sangiorgi, L., Campanacci, M. Histopathology (1994) [Pubmed]
  4. The effects of citric acid on phytate-phosphorus utilization in young chicks and pigs. Boling, S.D., Webel, D.M., Mavromichalis, I., Parsons, C.M., Baker, D.H. J. Anim. Sci. (2000) [Pubmed]
  5. Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device. Lafuente, M.P., Franch, J., Durall, I., Díaz-Bertrana, M.C., Márquez, R.M. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  6. The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb. Ros, M.A., Dahn, R.D., Fernandez-Teran, M., Rashka, K., Caruccio, N.C., Hasso, S.M., Bitgood, J.J., Lancman, J.J., Fallon, J.F. Development (2003) [Pubmed]
  7. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Goff, D.J., Tabin, C.J. Development (1997) [Pubmed]
  8. Absent fibula and craniosynostosis: a 25 year follow up. Lowry, R.B. J. Med. Genet. (1993) [Pubmed]
  9. Internal strains and stresses measured in cortical bone via high-energy X-ray diffraction. Almer, J.D., Stock, S.R. J. Struct. Biol. (2005) [Pubmed]
  10. Loss of fibula in mice overexpressing Hoxc11. Papenbrock, T., Visconti, R.P., Awgulewitsch, A. Mech. Dev. (2000) [Pubmed]
  11. Prolapsed intervertebral disc with sciatica: the role of common peroneal nerve block. Sangwan, S.S., Mittal, R., Kundu, Z.S., Siwach, R.C., Aggarwal, S., Garg, R.K. Tropical doctor. (2005) [Pubmed]
  12. Femoral infarction following intraarterial chemotherapy for osteosarcoma of the leg: a possible pitfall in magnetic resonance imaging. Ollivier, L., Leclere, J., Vanel, D., Forest, M., Pouillart, P., Riche, M.C., Tomeno, B. Skeletal radiology. (1991) [Pubmed]
  13. Potential role of fibroblast growth factor in enhancement of fracture healing. Radomsky, M.L., Thompson, A.Y., Spiro, R.C., Poser, J.W. Clin. Orthop. Relat. Res. (1998) [Pubmed]
  14. Treatment of severe atrophy of the maxilla with the prefabricated free vascularized fibula flap. Rohner, D., Bucher, P., Kunz, C., Hammer, B., Schenk, R.K., Prein, J. Clinical oral implants research. (2002) [Pubmed]
  15. Assessment of the incorporation of revascularized fibula grafts used for mandibular reconstruction with F-18-PET. Berding, G., Schliephake, H., van den Hoff, J., Knapp, W.H. Nuklearmedizin. (2001) [Pubmed]
  16. Interface of unloaded titanium implants in the iliac crest, fibula, and scapula: a histomorphometric and biomechanical study in the pig. Rohner, D., Tay, A., Chung, S.M., Hutmacher, D.W. The International journal of oral & maxillofacial implants. (2004) [Pubmed]
  17. Ankle stability after resection of the distal third of the fibula for giant-cell lesions: report of two cases. Yadav, S.S. Clin. Orthop. Relat. Res. (1981) [Pubmed]
  18. Localized polyartheritis nodosa in the lower limb with new bone formation. Brandrup, F., Peterson, E.M., Hansen, B.F., Hansen, B.F. Acta Derm. Venereol. (1980) [Pubmed]
  19. Use of the vascular closure staple clip applier for microvascular anastomosis in free-flap surgery. Cope, C., Lee, K., Stern, H., Pennington, D. Plast. Reconstr. Surg. (2000) [Pubmed]
  20. Contact characteristics of the subtalar joint: load distribution between the anterior and posterior facets. Wagner, U.A., Sangeorzan, B.J., Harrington, R.M., Tencer, A.F. J. Orthop. Res. (1992) [Pubmed]
  21. Blood supply to osteocutaneous free fibula flap and peroneus longus muscle: prospective anatomic study and clinical applications. Cho, B.C., Kim, S.Y., Park, J.W., Baik, B.S. Plast. Reconstr. Surg. (2001) [Pubmed]
  22. Chronic ethanol consumption results in deficient bone repair in rats. Chakkalakal, D.A., Novak, J.R., Fritz, E.D., Mollner, T.J., McVicker, D.L., Lybarger, D.L., McGuire, M.H., Donohue, T.M. Alcohol Alcohol. (2002) [Pubmed]
  23. Cervical myelopathy secondary to ossification of the posterior longitudinal ligament in a Caucasian patient. Maroun, F.B., Makino, A.P., Tong, T.R., Perkins, P.G., Arts, R., Jacob, J.C., Reddy, R. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1993) [Pubmed]
  24. Use of the "double barrel" free vascularized fibula in mandibular reconstruction. Bähr, W., Stoll, P., Wächter, R. J. Oral Maxillofac. Surg. (1998) [Pubmed]
  25. Osteonecrosis of the femoral head: comparison of clinical results for vascularized iliac and fibula bone grafting. Yen, C.Y., Tu, Y.K., Ma, C.H., Yu, S.W., Kao, F.C., Lee, M.S. Journal of reconstructive microsurgery. (2006) [Pubmed]
  26. Letter: Congenital absence of fibula. Fitch, N. J. Pediatr. (1975) [Pubmed]
  27. Radical resection for osteogenic sarcoma of fibula with preservation of the limb. Marcove, R.C., Jensen, M.J. Clin. Orthop. Relat. Res. (1977) [Pubmed]
  28. Ankle-arm index versus angiography for the preassessment of the fibula free flap. Klein, S., Hage, J.J., van der Horst, C.M., Lagerweij, M. Plast. Reconstr. Surg. (2003) [Pubmed]
  29. The treatment of ankle valgus by surface epiphysiodesis. Beals, R.K. Clin. Orthop. Relat. Res. (1991) [Pubmed]
  30. Mechanical failure of unsupported Huckstep intramedullary nail in malignant bone tumor reconstruction. Abe, S., Tateishi, A., Tokizaki, T., Takeyama, S., Nakano, H., Matsushita, T. Clin. Orthop. Relat. Res. (2001) [Pubmed]
  31. Mandibular augmentation with vascularized fibula transplantation in a patient with systemic lupus erythematosus. Li, L., Friedrich, R.E., Schmelzle, R. J. Oral Maxillofac. Surg. (2004) [Pubmed]
  32. Primary intraosseous fibrosarcoma of jaw. Pereira, C.M., Jorge, J., Di Hipólito, O., Kowalski, L.P., Lopes, M.A. International journal of oral and maxillofacial surgery. (2005) [Pubmed]
  33. Physiologic isolation of the canine proximal fibular epiphysis on a vascular pedicle. Nettelblad, H., Randolph, M.A., Weiland, A.J. Microsurgery. (1984) [Pubmed]
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