Disease relevance of Fibula

• Stress fractures of the distal fibula presenting as monarticular flares in patients with rheumatoid arthritis [1].
• Moreover, we confirm that cystic renal changes are an integral part of Hajdu-Cheney syndrome, and agree that Hajdu-Cheney syndrome and Serpentine fibula syndrome are probably variant examples of the same disease [2].
• Cytokeratin expression and distribution in adamantinoma of the long bones and osteofibrous dysplasia of tibia and fibula. An immunohistochemical study correlated to histogenesis [3].
• Weight gain and gain:feed data suggested a response to citric acid addition, but this was not supported by fibula ash results (P > .10) [4].
• Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device [5].

High impact information on Fibula

• Accordingly we classify the limb skeletal elements as Shh dependent or independent, with the ulna/fibula and digits other than digit 1 in the leg being Shh dependent [6].
• Hoxd-13 misexpression in the hindlimb results in a shortening of the long bones, including the femur, the tibia, the fibula and the tarsometatarsals [7].
• Absent fibula and craniosynostosis: a 25 year follow up [8].
• A transverse cross-section of a 12-14 year old beagle fibula was studied with 80.7 keV radiation, and the transmission geometry was used to quantify internal strains and corresponding stresses in the mineral phase, carbonated hydroxyapatite [9].
• Loss of fibula in mice overexpressing Hoxc11 [10].

Chemical compound and disease context of Fibula

• A total of 210 patients of Lumbar disc prolapse with sciatica were given common peroneal block by infiltrating 2% xylocaine around the common peroneal nerve 3 cm below the head of fibula on the affected side [11].
• Bone infarction of the distal femur is reported in two patients with osteosarcoma of the leg (1 tibia, 1 fibula) treated by preoperative chemotherapy including intraarterial chemotherapy (IAC) by Cis-platinum [12].

Biological context of Fibula

• Combined with the lack of an overt phenotype in the majority of Hoxc11 overexpressing embryos at day 13.5, the data suggest inhibition of chondrocyte differentiation during the elongation phase of the fibula bone as a primary effect of elevated Hoxc11 expression [10].
• When applied directly into a freshly created fracture in the rabbit fibula, a single injection of the basic fibroblast growth factor and hyaluronan results in the stimulation of callus formation, increased bone formation, and earlier restoration of mechanical strength at the fracture site [13].
• The reconstructions with the fibula flaps were successful and the 18 ITI implants that have been inserted showed good osseointegration without loss of attachment in all 4 patients after a mean observation period of 12 months [14].
• AIM: Determination of the range of regional blood flow and fluoride influx during normal incorporation of revascularized fibula grafts used for mandibular reconstruction [15].

Anatomical context of Fibula

• Interface of unloaded titanium implants in the iliac crest, fibula, and scapula: a histomorphometric and biomechanical study in the pig [16].
• This paper presents the augmentation of the maxilla with a prefabricated free vascularized fibula flap in combination with ITI implants (Straumann AG, Waldenburg, Switzerland) in 4 patients [14].
• Giant-cell tumors and aneurysmal bone cysts involving the lower end of fibula pose special management problems [17].
• A 61-year-old male patient, with a burned-out ankylosing spondylitis, developed polyarteritis in the right lower limb, associated with periosteal new bone formation in tibia and fibula [18].
• Of the 87 flaps there were 53 TRAM flaps, seven bilateral TRAM, five latissimus dorsi, four gastrocnemius, three rectus abdominis, two radial forearm fibula, and four Rubens fat-pad flaps [19].

Associations of Fibula with chemical compounds

• In the coronal plane, specimens were positioned in neutral, inversion, or eversion, and the contact characteristics were determined in varying positions, with and without loading the fibula, under axial loads of 350 N, 700 N, 1,050 N, and 1,400 N [20].
• The soleus and flexor hallucis longus muscles of the fibula were dissected, and the proximal part of the pedicle was reached [21].
• Rigidity of fibula in ethanol-fed rats and their pair-fed controls (groups A and B) were respectively 48 and 47% lower than in group C. Flexural modulus of the repair tissue in ethanol-fed rats had a 55% (P = 0.046) deficiency compared with their pair-fed controls [22].
• Medial corpectomy, C5 to C7, and removal of OPLL, with subsequent fusion C4 to T1 using a free fibula graft resulted in clinical improvement [23].
• However, because of the limited diameter of the fibula compared with the height of the mandible, the vertical distance between the reconstructed segment and the occlusal plane can be substantially large [24].

Gene context of Fibula

• Twenty-two patients with ANFH, who received free vascularized fibula bone grafting (Group 2) were followed for more than 3 years [25].
• Letter: Congenital absence of fibula [26].
• Radical resection for osteogenic sarcoma of fibula with preservation of the limb [27].
• Peripheral arterial occlusive disease or congenital anomalies of the major crural arteries may limit the use of the fibula free flap and should be detected preoperatively [28].
• Progressive ankle valgus in childhood requiring surgical correction is usually because of paralytic disease or conditions that produce a short distal fibula such as multiple exostoses or both [29].

Analytical, diagnostic and therapeutic context of Fibula

• This is a report of a 15 year old girl with osteogenic sarcoma of the proximal fibula treated by en bloc radical excision without amputation of the limb [27].
• Seventeen segmental resections of diaphyseal tumors and five knee resection arthrodeses were reconstructed using the Huckstep nail with intercalary bone grafts (fibula), cementation, and ceramic and titanium spacers [30].
• Mandibular augmentation with vascularized fibula transplantation in a patient with systemic lupus erythematosus [31].
• The patient underwent tumor surgical resection, supraomohyoid neck dissection and mandible reconstruction with fibula flap and titanium bar [32].
• Dissection of latex-injected adult and juvenile dogs established the vascular supply to the proximal canine fibula [33].

References