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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Spag9  -  sperm associated antigen 9

Mus musculus

Synonyms: 3110018C07Rik, 4733401I23Rik, 4831406C20Rik, AW552012, C-Jun-amino-terminal kinase-interacting protein 4, ...
 
 
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High impact information on Spag9

  • Activation of p38{alpha}/{beta} MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo [1].
  • Like other members of the JIP family of scaffold proteins, JIP4 binds JNK and also the light chain of the microtubule motor protein kinesin-1 [2].
  • The primary sequence of JIP4 is most closely related to that of JIP3 [2].
  • The JIP4 scaffold protein therefore appears to be a new component of the p38 MAP kinase signaling pathway [2].
  • Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways [2].
 

Associations of Spag9 with chemical compounds

  • JLP is a proline-rich protein that contains two leucine zipper domains and a highly conserved C-terminal domain [3].
  • Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein [4].
 

Other interactions of Spag9

  • Specifically, JIP4 does not activate JNK signaling [2].
  • Mutations of Leu-280, Leu-287, Val-294, and Leu-301 within this domain of KLC1 disrupted its ability to associate with JLP [3].

References

  1. Activation of p38{alpha}/{beta} MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo. Takaesu, G., Kang, J.S., Bae, G.U., Yi, M.J., Lee, C.M., Reddy, E.P., Krauss, R.S. J. Cell Biol. (2006) [Pubmed]
  2. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Kelkar, N., Standen, C.L., Davis, R.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain. Nguyen, Q., Lee, C.M., Le, A., Reddy, E.P. J. Biol. Chem. (2005) [Pubmed]
  4. Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. Kashef, K., Xu, H., Reddy, E.P., Dhanasekaran, D.N. J. Cell. Biochem. (2006) [Pubmed]
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