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Gene Review

Mapk8ip3  -  mitogen-activated protein kinase 8...

Mus musculus

Synonyms: BB120594, C-Jun-amino-terminal kinase-interacting protein 3, D17Wsu15e, JIP-3, JNK MAP kinase scaffold protein 3, ...
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Disease relevance of Mapk8ip3

  • The JSAP1-null embryonic stem cells were viable, however, exhibited hyperplasia of the ectoderm during embryoid body formation, and spontaneously differentiated into neurons more efficiently than did wild type [1].
  • We also showed that the expression of JSAP1 transcripts and proteins gradually increased during the neural differentiation of mouse P19 embryonal carcinoma (EC) cells [2].
  • The level of JSAP1 mRNA correlated with advanced malignancy in brain tumors, unlike other JIPs [3].

High impact information on Mapk8ip3


Biological context of Mapk8ip3


Anatomical context of Mapk8ip3

  • In the neurons differentiated from the wild type embryoid bodies, JSAP1 was localized in the soma, neurites, and growth cone-like structure of the neurites, and neurite outgrowth from the JSAP1-null embryoid bodies was apparently less efficient than from wild type [1].
  • The axon guidance defect of the corpus callosum in the jsap1-/- brain was correlated with the misplacement of glial sling cells, which reverted to their normal position after the transgenic expression of JNK interacting protein 1(JIP1) [7].
  • The JSAP1 null mutation impaired the normal distribution of the Ca+2 regulating protein, calretinin, but not the synaptic vesicle marker, SNAP-25, along the axons of the thalamocortical tract [7].
  • In contrast, expression of C-terminally truncated forms of JIP3 impaired LPS-induced JNK activation in a mouse macrophage cell line, RAW264 [4].
  • In contrast, only the activated form of SEK1 associated with JSAP1 in cotransfected COS-7 cells [8].

Associations of Mapk8ip3 with chemical compounds

  • Retinoic acid dramatically increased the expression of JSAP1 and JNK3, which were co-precipitated with anti-JNK3 in the neuroectoderm of wild type but not JSAP1-null embryoid bodies [1].

Other interactions of Mapk8ip3


Analytical, diagnostic and therapeutic context of Mapk8ip3


  1. In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. Xu, P., Yoshioka, K., Yoshimura, D., Tominaga, Y., Nishioka, T., Ito, M., Nakabeppu, Y. J. Biol. Chem. (2003) [Pubmed]
  2. Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. Akechi, M., Ito, M., Uemura, K., Takamatsu, N., Yamashita, S., Uchiyama, K., Yoshioka, K., Shiba, T. Neurosci. Res. (2001) [Pubmed]
  3. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. Takino, T., Nakada, M., Miyamori, H., Watanabe, Y., Sato, T., Gantulga, D., Yoshioka, K., Yamada, K.M., Sato, H. J. Biol. Chem. (2005) [Pubmed]
  4. JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. Matsuguchi, T., Masuda, A., Sugimoto, K., Nagai, Y., Yoshikai, Y. EMBO J. (2003) [Pubmed]
  5. Isoforms of JSAP1 scaffold protein generated through alternative splicing. Ito, M., Akechi, M., Hirose, R., Ichimura, M., Takamatsu, N., Xu, P., Nakabeppu, Y., Tadayoshi, S., Yamamoto, K., Yoshioka, K. Gene (2000) [Pubmed]
  6. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Kelkar, N., Delmotte, M.H., Weston, C.R., Barrett, T., Sheppard, B.J., Flavell, R.A., Davis, R.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1. Ha, H.Y., Cho, I.H., Lee, K.W., Lee, K.W., Song, J.Y., Kim, K.S., Yu, Y.M., Lee, J.K., Song, J.S., Yang, S.D., Shin, H.S., Han, P.L. Dev. Biol. (2005) [Pubmed]
  8. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., Yamamoto, K.I. Mol. Cell. Biol. (1999) [Pubmed]
  9. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Kelkar, N., Standen, C.L., Davis, R.J. Mol. Cell. Biol. (2005) [Pubmed]
  10. Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA. Sano, Y., Shimada, T., Nakashima, H., Nicholson, R.H., Eliason, J.F., Kocarek, T.A., Ko, M.S. Genome Res. (2001) [Pubmed]
  11. Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. Miura, E., Fukaya, M., Sato, T., Sugihara, K., Asano, M., Yoshioka, K., Watanabe, M. J. Neurochem. (2006) [Pubmed]
  12. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Kelkar, N., Gupta, S., Dickens, M., Davis, R.J. Mol. Cell. Biol. (2000) [Pubmed]
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