The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SPAG9  -  sperm associated antigen 9

Homo sapiens

Synonyms: C-Jun-amino-terminal kinase-interacting protein 4, CT89, Cancer/testis antigen 89, FLJ13450, FLJ14006, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SPAG9


Psychiatry related information on SPAG9

  • Event-related potentials (ERPs) were examined in 16 college students who had high scores on the Schizophrenia Scale of the MMPI (HSS) but were without a hereditary disposition for major psychiatric disorders [5].
  • The experimental groups (L and P type dyslexia) were presented with hemisphere specific stimulation (HSS) and hemispheric alluding stimuli (HAS) [6].
  • Hybridization tests among the four laboratory-raised isolines of An. aconitus Form B (Chiang Mai and Phet Buri) and C (Chiang Mai and Mae Hong Son) were employed by induced copulation [7].

High impact information on SPAG9

  • Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein [8].
  • Activation of p38{alpha}/{beta} MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo [9].
  • One candidate, sunday driver, is proposed to both link kinesin-I to an unknown vesicular cargo and to bind and organize the mitogen-activated protein kinase components of a c-Jun N-terminal kinase signaling module [10].
  • PHET appeared to be a member of the UniGene cluster Hs.129872, but had a unique exon composition and a characteristic mRNA expression profile restricted to the testis [11].
  • These findings suggest that the autoantibody response to PHET can be induced by ectopic overexpression of PHET in dermal fibroblasts in SSc patients [11].

Biological context of SPAG9

  • Microsequencing of higher-order aggregates of recombinant SPAG9 by tandem MS confirmed the amino acid sequence and mono atomic mass of 83.9 kDa [12].
  • SPAG9, a single copy gene mapped to the human chromosome 17q21.33 syntenic with location of mouse chromosome 11, was earlier shown to be expressed exclusively in testis [Shankar, Mohapatra and Suri (1998) Biochem. Biophys. Res. Commun. 243, 561-565] [12].
  • Transient expression of SPAG9 and its deletion mutants revealed that both leucine zipper with extended coiled-coil domains and transmembrane domain of SPAG9 were essential for dimerization and proper localization [12].
  • NCBI Blast searches revealed SPAG9 nucleotide sequence similarities with ESTs of various cancerous tissues [13].
  • The present investigation will eventually extend the application of SPAG9 siRNA in in vivo targeting experiments that aim to define the SPAG9 functional genomics in tumor and reproductive biology [13].

Anatomical context of SPAG9

  • Polyclonal antibodies raised against recombinant SPAG9 recognized native protein in human sperm extracts and localized specifically on the acrosomal compartment of intact human spermatozoa [12].
  • Further, anti-SPAG9 antibodies inhibited the binding of human spermatozoa to intact human oocytes as well as to matched hemizona [12].
  • Northern analysis and RNA in situ hybridization experiments revealed testis- and stage-specific expressions of macaque SPAG9 mRNA, mainly confined to round spermatid suggesting haploid germ cell expression [14].
  • SPAG9 is an acrosomal molecule which is not only restricted to a specific region (domain) of the acrosome but also undergoes relocation to the equatorial region in a stage-specific manner during acrosome reaction, demonstrating its potential role in sperm-egg binding [15].
  • In this study we describe SSc-specific autoantibody to a novel testicular Ag, termed protein highly expressed in testis (PHET), which is ectopically overexpressed in SSc dermal fibroblasts [11].

Associations of SPAG9 with chemical compounds


Other interactions of SPAG9


Analytical, diagnostic and therapeutic context of SPAG9


  1. Characterization of immune response in mice to plasmid DNA encoding human sperm associated antigen 9 (SPAG9). Jagadish, N., Rana, R., Mishra, D., Garg, M., Selvi, R., Suri, A. Vaccine (2006) [Pubmed]
  2. Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand. Endy, T.P., Nisalak, A., Chunsuttiwat, S., Libraty, D.H., Green, S., Rothman, A.L., Vaughn, D.W., Ennis, F.A. Am. J. Epidemiol. (2002) [Pubmed]
  3. Leptospirosis in kamphaeng phet, Thailand. Myint, K.S., Gibbons, R.V., Murray, C.K., Rungsimanphaiboon, K., Supornpun, W., Sithiprasasna, R., Gray, M.R., Pimgate, C., Mammen, M.P., Hospenthal, D.R. Am. J. Trop. Med. Hyg. (2007) [Pubmed]
  4. Capsid protein VP1 deletions in JC virus from two AIDS patients with progressive multifocal leukoencephalopathy. Stoner, G.L., Ryschkewitsch, C.F. J. Neurovirol. (1995) [Pubmed]
  5. Deviate P200 and P300 in non-patient college students with high scores on the schizophrenia scale of the Minnesota Multiphasic Personality Inventory (MMPI). Ogura, C., Hirano, K., Nageishi, Y., Takeshita, S., Fukao, K., Hokama, H., Ohta, H., Arakaki, H. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. (1994) [Pubmed]
  6. Neuropsychological treatment of dyslexia in the classroom setting. Goldstein, B.H., Obrzut, J.E. Journal of learning disabilities. (2001) [Pubmed]
  7. Evidence to support two conspecific cytological races on Anopneles aconitus in Thailand. Junkum, A., Komalamisra, N., Jitpakdi, A., Jariyapan, N., Min, G.S., Park, M.H., Cho, K.H., Somboon, P., Bates, P.A., Choochote, W. J. Vector Ecol. (2005) [Pubmed]
  8. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Bowman, A.B., Kamal, A., Ritchings, B.W., Philp, A.V., McGrail, M., Gindhart, J.G., Goldstein, L.S. Cell (2000) [Pubmed]
  9. Activation of p38{alpha}/{beta} MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo. Takaesu, G., Kang, J.S., Bae, G.U., Yi, M.J., Lee, C.M., Reddy, E.P., Krauss, R.S. J. Cell Biol. (2006) [Pubmed]
  10. Kinesin molecular motors: transport pathways, receptors, and human disease. Goldstein, L.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  11. A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. Yasuoka, H., Ihn, H., Medsger, T.A., Hirakata, M., Kawakami, Y., Ikeda, Y., Kuwana, M. J. Immunol. (2003) [Pubmed]
  12. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. Jagadish, N., Rana, R., Selvi, R., Mishra, D., Garg, M., Yadav, S., Herr, J.C., Okumura, K., Hasegawa, A., Koyama, K., Suri, A. Biochem. J. (2005) [Pubmed]
  13. Small interference RNA-mediated knockdown of sperm associated antigen 9 having structural homology with c-Jun N-terminal kinase-interacting protein. Rana, R., Jagadish, N., Garg, M., Mishra, D., Dahiya, N., Chaurasiya, D., Suri, A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  14. Molecular cloning and characterization of the macaque sperm associated antigen 9 (SPAG9): an orthologue of human SPAG9 gene. Jagadish, N., Rana, R., Selvi, R., Mishra, D., Shankar, S., Mohapatra, B., Suri, A. Mol. Reprod. Dev. (2005) [Pubmed]
  15. Immunogenicity and contraceptive potential of recombinant human sperm associated antigen (SPAG9). Jagadish, N., Rana, R., Mishra, D., Garg, M., Chaurasiya, D., Hasegawa, A., Koyama, K., Suri, A. J. Reprod. Immunol. (2005) [Pubmed]
  16. Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis. Jagadish, N., Rana, R., Mishra, D., Kumar, M., Suri, A. The Keio journal of medicine. (2005) [Pubmed]
  17. Identification of a distinct 9S form of soluble clathrin in cultured cells and tissues. Bruder, G., Wiedenmann, B. Exp. Cell Res. (1986) [Pubmed]
  18. Redox regulation of sperm surface thiols modulates adhesion to the fallopian tube epithelium. Talevi, R., Zagami, M., Castaldo, M., Gualtieri, R. Biol. Reprod. (2007) [Pubmed]
  19. Two-dimensional gel electrophoretic analysis of vectorially labeled surface proteins of human spermatozoa. Naaby-Hansen, S., Flickinger, C.J., Herr, J.C. Biol. Reprod. (1997) [Pubmed]
  20. Dimeric forms of cholinesterase in Sipunculus nudus. Talesa, V., Principato, G.B., Giovannini, E., Di Giovanni, M.V., Rosi, G. Eur. J. Biochem. (1993) [Pubmed]
  21. Sperm surface proteins after capacitation. Expression of vitronectin on the spermatozoan head and laminin on the sperm tail. Fusi, F.M., Lorenzetti, I., Vignali, M., Bronson, R.A. J. Androl. (1992) [Pubmed]
  22. Semen LDH-X deficiency and male infertility. Gavella, M., Cvitković, P. Arch. Androl. (1985) [Pubmed]
  23. Isolation and characterization of a haploid germ cell specific sperm associated antigen 9 (SPAG9) from the baboon. Shankar, S., Mohapatra, B., Verma, S., Selvi, R., Jagadish, N., Suri, A. Mol. Reprod. Dev. (2004) [Pubmed]
  24. Immunogenicity study of recombinant human sperm-associated antigen 9 in bonnet macaque (Macaca radiata). Rana, R., Jagadish, N., Garg, M., Mishra, D., Dahiya, N., Chaurasiya, D., Suri, A. Hum. Reprod. (2006) [Pubmed]
WikiGenes - Universities