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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Car13  -  carbonic anhydrase 13

Mus musculus

Synonyms: 2310075C21Rik, CA-XIII, Ca13, Carbonate dehydratase XIII, Carbonic anhydrase 13, ...
 
 
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High impact information on Car13

  • In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs [1].
  • Recent analyses of human and mouse databases provided evidence that human and mouse genomes contain genes for still another novel CA isozyme hereby named CA XIII [1].
  • In the neonatal mouse uterus, Car2 and Car11 mRNAs were predominantly localized in endometrial epithelial and stromal cells, respectively, whereas Car13 mRNA was detected in both epithelia and stroma [2].
  • Importantly, Car1, Car3, and Car13 showed very high expression levels in certain tissues as compared to the other CAs, suggesting that these low activity isozymes may also participate in physiological processes other than CA catalysis and high expression levels are required to fulfil their functions in the body [3].

References

  1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. Lehtonen, J., Shen, B., Vihinen, M., Casini, A., Scozzafava, A., Supuran, C.T., Parkkila, A.K., Saarnio, J., Kivelä, A.J., Waheed, A., Sly, W.S., Parkkila, S. J. Biol. Chem. (2004) [Pubmed]
  2. Carbonic anhydrase regulate endometrial gland development in the neonatal uterus. Hu, J., Spencer, T.E. Biol. Reprod. (2005) [Pubmed]
  3. A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system. Pan, P.W., Rodriguez, A., Parkkila, S. BMC Mol. Biol. (2007) [Pubmed]
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