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Prcp  -  prolylcarboxypeptidase (angiotensinase C)

Mus musculus

Synonyms: 2510048K03Rik, 2610104A14Rik, AI451719, HUMPCP, Lysosomal Pro-X carboxypeptidase, ...
 
 
 
 
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High impact information on Prcp

  • PCP-induced decrease in the number of BrdU-labeled cells was negated by co-administration of clozapine, but not haloperidol, although repeated antipsychotics treatment by themselves had no effect [1].
  • Repeated administration of PCP and MK-801, but not METH, resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus [1].
  • Furthermore, co-administration of D-serine and glycine, but not L-serine, inhibited the PCP-induced decrease in the number of BrdU-labeled cells [1].
 

Associations of Prcp with chemical compounds

  • Since repeated administration of psychostimulants such as phencyclidine (PCP), MK-801, and methamphetamine (METH) induces schizophrenia-like behavioral changes in animals, we investigated whether repeated administration of these psychostimulants affects neurogenesis in the dentate gyrus of mice [1].

References

  1. Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. Maeda, K., Sugino, H., Hirose, T., Kitagawa, H., Nagai, T., Mizoguchi, H., Takuma, K., Yamada, K. J. Pharmacol. Sci. (2007) [Pubmed]
 
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