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Gene Review

TUBB2A  -  tubulin, beta 2A class IIa

Homo sapiens

Synonyms: CDCBM5, TUBB, TUBB2, Tubulin beta class IIa, Tubulin beta-2A chain, ...
 
 
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High impact information on TUBB2A

  • An expressed beta-tubulin gene, TUBB, is located on the short arm of human chromosome 6 and two related sequences are dispersed on chromosomes 8 and 13 [1].
  • This location suggests that a mutation at the TUBB locus could be the cause for certain forms of HLA-linked microtubule dysfunction, including immotile cilia syndrome [2].
  • 3. A long range restriction map including TUBB and several HLA class I genes was then generated by rotating field gel electrophoresis [2].
  • By using a panel of deletion mutant cell lines and radiation-reduced hybrids containing fragments of chromosome 6, the TUBB locus could be mapped to the HLA class I region at 6p21 [2].
  • Between down regulated genes, API5, TUBB2 and TLK1 are also of considerable interest [3].
 

Anatomical context of TUBB2A

  • Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction [2].

References

 
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