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Gene Review

API5  -  apoptosis inhibitor 5

Homo sapiens

Synonyms: AAC-11, AAC11, API-5, API5L1, Antiapoptosis clone 11 protein, ...
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Disease relevance of API5


High impact information on API5

  • FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2 [4].
  • In contrast to the full-length FIF protein, several deletion constructs were able to transactivate a lac-Z reporter gene [4].
  • In contrast, in adult human corneas the adrenergic nerves could be identified only with the SPG technique, whereas with FIF the identification of specific catecholamine fluoresence was not possible due to extensive collagen autofluorescence [5].
  • The techniques included both sodium-potassium-glyoxylic acid-induced fluorescence (SPG) and formaldehyde-induced fluorescence after freeze-drying (FIF) procedure [5].
  • In fetal corneas the presence of adrenergic nerve fibers could be demonstrated by both SPG and FIF techniques [5].

Biological context of API5

  • AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis [6].
  • AAC-11 gene transfection increased cervical cancer cell colonization [6].
  • These results suggest that the molecular structure of FIF is very specific for the factor C activity [7].
  • There was no relationship between AAC-11 gene expression and age, gender, N or T-status [2].
  • FIF activity was lost following treatment with trypsin, chymotrypsin, and neuraminidase and FIF could not be generated in the presence of inhibitors of glycosylation, suggesting that the molecule was a glycoprotein [8].

Anatomical context of API5


Associations of API5 with chemical compounds


Other interactions of API5


Analytical, diagnostic and therapeutic context of API5

  • Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene [15].
  • Gel filtration revealed two peaks of FIF activity 15,000 and at 34,000 Da [8].
  • 1--The innervation of the liver and gallbladder of Rana ridibunda has been studied by the following methods: (a) demonstration of cholinesterase activity; (b) FIF method for catecholamines; (c) immunohistochemistry for VIP and (d) electron microscopy [16].
  • This case report highlights the use of prenatal MRI to confirm prenatal diagnosis of an intra-abdominal FIF to aid obstetricians, neonatologists, and pediatric general surgeons in perinatal and surgical management [17].


  1. Abdominal parasitic twin: an unusual cause of duodenal obstruction. Blumberg, N.A. The British journal of surgery. (1980) [Pubmed]
  2. Expression of the antiapoptosis gene, AAC-11, as a prognosis marker in non-small cell lung cancer. Sasaki, H., Moriyama, S., Yukiue, H., Kobayashi, Y., Nakashima, Y., Kaji, M., Fukai, I., Kiriyama, M., Yamakawa, Y., Fujii, Y. Lung Cancer (2001) [Pubmed]
  3. Flow-volume curves in obstructive sleep apnea and snoring. Rauscher, H., Popp, W., Zwick, H. Lung (1990) [Pubmed]
  4. FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. Van den Berghe, L., Laurell, H., Huez, I., Zanibellato, C., Prats, H., Bugler, B. Mol. Endocrinol. (2000) [Pubmed]
  5. Histochemical demonstration of adrenergic nerves in the stroma of human cornea. Toivanen, M., Tervo, T., Partanen, M., Vannas, A., Hervonen, A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  6. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. Kim, J.W., Cho, H.S., Kim, J.H., Hur, S.Y., Kim, T.E., Lee, J.M., Kim, I.K., Namkoong, S.E. Lab. Invest. (2000) [Pubmed]
  7. Stress-induced factor involved in flower formation of Lemna is an alpha-ketol derivative of linolenic acid. Yokoyama, M., Yamaguchi, S., Inomata, S., Komatsu, K., Yoshida, S., Iida, T., Yokokawa, Y., Yamaguchi, M., Kaihara, S., Takimoto, A. Plant Cell Physiol. (2000) [Pubmed]
  8. Physicochemical characterization of human fibroblast migration inhibitory factor. Hamel, J., Rola-Pleszczynski, M. Cell. Immunol. (1985) [Pubmed]
  9. The autonomic innervation of the liver and gallbladder of Podarcis hispanica. Azanza, M.J., Aisa, J., Junquera, C. Histol. Histopathol. (1990) [Pubmed]
  10. Intrinsic and extrinsic innervation of the amphibians esophagic myenteric plexuses. Junquera, C., Azanza, M.J., Parra, P., Peg, M.T., Aisa, J., Romero, L.M., Garín, P. Histol. Histopathol. (1988) [Pubmed]
  11. Ultrastructure and histochemistry of human SIF cells and paraganglia. Helén, P., Alho, H., Hervonen, A. Adv. Biochem. Psychopharmacol. (1980) [Pubmed]
  12. Contamination levels and preliminary assessment of the technical feasibility of employing natural attenuation in 5 priority areas of presidente bernardes refinery in cubatão, são paulo, Brazil. Schneider, R.P., Morano, S.C., Gigena, M.A., Missawa, S.K., Rocha, R.C., Silva, L.R., Ellert, N., Kataoka, S., Katsuragi, C., Rosa, C.d.a. .S., Filho, L.C. Environmental monitoring and assessment. (2006) [Pubmed]
  13. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Whang, W.K., Park, H.S., Ham, I., Oh, M., Namkoong, H., Kim, H.K., Hwang, D.W., Hur, S.Y., Kim, T.E., Park, Y.G., Kim, J.R., Kim, J.W. Exp. Mol. Med. (2005) [Pubmed]
  14. cDNA microarray study to identify expression changes relevant for apoptosis in K562 cells co-treated with amifostine and imatinib. Bianchini, M., Martinelli, G., Renzulli, M., Gonzalez Cid, M., Larripa, I. Cancer Chemother. Pharmacol. (2007) [Pubmed]
  15. Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. Gianfrancesco, F., Esposito, T., Ciccodicola, A., D'Esposito, M., Mazzarella, R., D'Urso, M., Forabosco, A. Cytogenet. Cell Genet. (1999) [Pubmed]
  16. The autonomic innervation of the liver and gallbladder of Rana ridibunda. Azanza, M.J., Aisa, J., Junquera, C., Castiella, T. Histol. Histopathol. (1989) [Pubmed]
  17. Fetus-in-fetu: confirmation of prenatal diagnosis with MRI. Coolen, J., Bradshaw, B., Bhargava, R., Lees, G., Demianczuk, N. Prenat. Diagn. (2007) [Pubmed]
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