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Gene Review

Ift57  -  intraflagellar transport 57

Mus musculus

Synonyms: 4833420A15Rik, Esrrbl1, HIP1-interacting protein, HIPPI, Hippi, ...
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Psychiatry related information on Ift57


High impact information on Ift57

  • This heterodimer can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway [2].
  • Hippi functions as an adapter protein that mediates pro-apoptotic signaling from poly-glutamine-expanded huntingtin, an established cause of Huntington disease, to the extrinsic cell death pathway [3].
  • Together, these findings demonstrate a dual role for Hippi in cilia assembly and Shh signaling during development, in addition to its proposed role in apoptosis signal transduction in the adult brain under pathogenically stressful conditions [3].
  • Homer1c interacts with Hippi and protects striatal neurons from apoptosis [1].


  1. Homer1c interacts with Hippi and protects striatal neurons from apoptosis. Sakamoto, K., Yoshida, S., Ikegami, K., Minakami, R., Kato, A., Udo, H., Sugiyama, H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  2. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Gervais, F.G., Singaraja, R., Xanthoudakis, S., Gutekunst, C.A., Leavitt, B.R., Metzler, M., Hackam, A.S., Tam, J., Vaillancourt, J.P., Houtzager, V., Rasper, D.M., Roy, S., Hayden, M.R., Nicholson, D.W. Nat. Cell Biol. (2002) [Pubmed]
  3. Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Houde, C., Dickinson, R.J., Houtzager, V.M., Cullum, R., Montpetit, R., Metzler, M., Simpson, E.M., Roy, S., Hayden, M.R., Hoodless, P.A., Nicholson, D.W. Dev. Biol. (2006) [Pubmed]
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